INSIDE Project: Individual Air Pollution Exposure, Extracellular Vesicles Signaling and Hypertensive Disorder Development in Pregnancy

Luca Ferrari, Francesca Borghi, Simona Iodice, Dolores Catelan, Stefano Rossi, Ilaria Giusti, Laura Grisotto, Sabrina Rovelli, Andrea Spinazzè, Rossella Alinovi, Silvana Pinelli, Laura Cantone, Laura Dioni, Benedetta Ischia, Irene Rota, Jacopo Mariani, Federica Rota, Mirjam Hoxha, Giorgia Stoppa, Damiano Monticelli, Domenico Cavallo, Enrico Bergamaschi, Marco Vicenzi, Nicola Persico, Annibale Biggeri, Andrea Cattaneo, Vincenza Dolo, Michele Miragoli, Paola Mozzoni and Valentina Bollati
Additional contact information
Luca Ferrari: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Francesca Borghi: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Simona Iodice: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Dolores Catelan: Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy
Stefano Rossi: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Ilaria Giusti: Department of Life, Health and Environmental Sciences, Università degli Studi dell’Aquila, 67100 L’Aquila, Italy
Laura Grisotto: Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy
Sabrina Rovelli: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Andrea Spinazzè: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Rossella Alinovi: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Silvana Pinelli: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Laura Cantone: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Laura Dioni: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Benedetta Ischia: Department of Obstetrics and Gynecology ‘L. Mangiagalli’, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Irene Rota: Cardiovascular Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Jacopo Mariani: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Federica Rota: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Mirjam Hoxha: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy
Giorgia Stoppa: Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy
Damiano Monticelli: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Domenico Cavallo: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Enrico Bergamaschi: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Marco Vicenzi: Cardiovascular Disease Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Nicola Persico: Department of Obstetrics and Gynecology ‘L. Mangiagalli’, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Annibale Biggeri: Department of Statistics, Computer Science and Applications “G. Parenti”, Università degli Studi di Firenze, 50134 Florence, Italy
Andrea Cattaneo: Department of Science and High Technology, Università degli Studi dell’Insubria, 22100 Como, Italy
Vincenza Dolo: Department of Life, Health and Environmental Sciences, Università degli Studi dell’Aquila, 67100 L’Aquila, Italy
Michele Miragoli: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Paola Mozzoni: Center of Excellence for Toxicological Research, Department of Medicine and Surgery, Università degli Studi di Parma, 43121 Parma, Italy
Valentina Bollati: EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20122 Milan, Italy

IJERPH, 2020, vol. 17, issue 23, 1-14

Abstract: Hypertensive disorders are common complications during pregnancy (HDP) with substantial public health impact. Acute and chronic particulate matter (PM) exposure during pregnancy increases the risk of HDP, although the underlying molecular mechanisms remain unclear. Extracellular vesicles (EVs) may be the ideal candidates for mediating the effects of PM exposure in pregnancy as they are released in response to environmental stimuli. The INSIDE project aims to investigate this mechanism in pregnancy outcomes. The study population is enrolled at the Fetal Medicine Unit of Fondazione IRCCS Ca’Granda—Ospedale Maggiore Policlinico at 10–14 weeks of gestation. Exposure to PM 10 and PM 2.5 is assessed using the flexible air quality regional model (FARM) and Bayesian geostatistical models. Each woman provides a blood sample for EV analysis and circulating biomarker assessment. Moreover, a subgroup of recruited women (n = 85) is asked to participate in a cardiovascular screening program including a standard clinical evaluation, a non-invasive assessment of right ventricular function, and pulmonary circulation at rest and during exercise. These subjects are also asked to wear a personal particulate sampler, to measure PM 10 , PM 2.5 , and PM 1 . The INSIDE study is expected to identify the health impacts of PM exposure on pregnancy outcomes.

Keywords: air pollution exposure; hypertensive disorder development; pregnancy; extracellular vesicles (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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