Effect of Chinese Propolis as an Intracanal Medicament on Post-Operative Endodontic Pain: A Double-Blind Randomized Controlled Trial

Juzer Shabbir, Fazal Qazi, Waqas Farooqui, Shahbaz Ahmed, Tazeen Zehra and Zohaib Khurshid
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Juzer Shabbir: Department of Operative Dentistry & Endodontics, Dow International Dental College, Dow University of Health Sciences, Karachi 74200, Pakistan
Fazal Qazi: Department of Operative Dentistry & Endodontics, Dr. Ishrat-ul-ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 72400, Pakistan
Waqas Farooqui: School of Public Health, Dow University of Health Sciences, Karachi 74200, Pakistan
Shahbaz Ahmed: Department of Operative Dentistry & Endodontics, Dr. Ishrat-ul-ibad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 72400, Pakistan
Tazeen Zehra: Liaquat College of Medicine and Dentistry, Operative Dentistry Department, Karachi 75290, Pakistan
Zohaib Khurshid: Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al Ahsa 31982, Saudi Arabia

IJERPH, 2020, vol. 17, issue 2, 1-10

Abstract: Propolis is a potent anti-microbial and natural anti-inflammatory by-product obtained from the beehive. Studies have demonstrated the superior biocompatibility and anti-microbial properties of propolis as compared to calcium hydroxide. However, its effect on postoperative endodontic pain is unknown. Therefore, this study aimed to investigate the impact of Chinese propolis paste as an intracanal medicament on postoperative endodontic pain intensities compared with calcium hydroxide (control) at different time intervals in necrotic teeth with periapical radiolucency. Eighty patients with single-rooted necrotic teeth with visible periapical radiolucency were recruited and randomly allocated to either the calcium hydroxide or propolis groups. After chemo-mechanical preparation and intracanal medicament insertion, patients were given the VAS (visual analogue scale) to record pain scores. Inter-group data were compared and analyzed using two-way repeated measure ANOVA (Bonferroni test). A p -value of < 0.025 was considered significant. In total, >78% of the patients experienced no or only mild post-operative pain in both the groups at all time intervals, without any significant difference in pain scores between the two groups ( p > 0.025). An overall flare-up rate of 14.8% was found. The results suggest that either of these medicaments can be used as an inter-appointment medication for the prevention of postoperative pain in necrotic cases.

Keywords: calcium hydroxide; propolis; postoperative pain; natural product; clinical trial (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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