Use of Medications by Breastfeeding Women in the 2015 Pelotas (Brazil) Birth Cohort Study

Bárbara Heather Lutz, Diego Garcia Bassani, Vanessa Iribarrem Avena Miranda, Marysabel Pinto Telis Silveira, Sotero Serrate Mengue, Tatiane da Silva Dal Pizzol, Mariângela Freitas da Silveira and Andréa Dâmaso Bertoldi
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Bárbara Heather Lutz: Department of Social Medicine, Faculty of Medicine, Federal University of Pelotas, Avenida Duque de Caxias, 250, Pelotas 96030-000, RS, Brazil
Diego Garcia Bassani: Centre for Global Child Health, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Vanessa Iribarrem Avena Miranda: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160, Pelotas 96020-220, RS, Brazil
Marysabel Pinto Telis Silveira: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160, Pelotas 96020-220, RS, Brazil
Sotero Serrate Mengue: Post-Graduate Program in Epidemiology, Federal University of Porto Alegre, Av. Ipiranga, 2752, Sala 203, Porto Alegre 96020-000, RS, Brazil
Tatiane da Silva Dal Pizzol: Post-Graduate Program in Epidemiology, Federal University of Porto Alegre, Av. Ipiranga, 2752, Sala 203, Porto Alegre 96020-000, RS, Brazil
Mariângela Freitas da Silveira: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160, Pelotas 96020-220, RS, Brazil
Andréa Dâmaso Bertoldi: Post-Graduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160, Pelotas 96020-220, RS, Brazil

IJERPH, 2020, vol. 17, issue 2, 1-16

Abstract: Background: This study describes medication use by women up to 3 months postpartum and evaluates the association between medication use by women who were still breastfeeding at 3 months postpartum and weaning at 6 and 12 months. Methods: Population-based cohort, including women who breastfed ( n = 3988). Medications were classified according to Hale’s lactation risk categories and Brazilian Ministry of Health criteria. Duration of breastfeeding was analysed using Cox regression models and Kaplan-Meier curves, including only women who were still breastfeeding at three months postpartum. Results: Medication use with some risk for lactation was frequent (79.6% regarding Hale’s risk categories and 12.3% regarding Brazilian Ministry of Health criteria). We did not find statistically significant differences for weaning at 6 or 12 months between the group who did not use medication or used only compatible medications and the group who used medications with some risk for lactation, according to both criteria. Conclusions: Our study found no association between weaning rates across the different breastfeeding safety categories of medications in women who were still breastfeeding at three months postpartum. Therefore, women who took medications and stopped breastfeeding in the first three months postpartum because of adverse side-effects associated with medications could not be addressed in this analysis.

Keywords: pharmacoepidemiology; breastfeeding; drug utilization; pharmaceutical preparations; cohort studies; weaning; risk assessment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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