Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women

Eunjung Lee, April Kinninger, Giske Ursin, Chiuchen Tseng, Susan Hurley, Miaomiao Wang, Yunzhu Wang, June-Soo Park, Myrto Petreas, Dennis Deapen and Peggy Reynolds
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Eunjung Lee: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
April Kinninger: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Giske Ursin: Cancer Registry of Norway, 0304 Oslo, Norway
Chiuchen Tseng: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Susan Hurley: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94704, USA
Miaomiao Wang: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA 94710, USA
Yunzhu Wang: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA 94710, USA
June-Soo Park: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA 94710, USA
Myrto Petreas: Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA 94710, USA
Dennis Deapen: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
Peggy Reynolds: Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94704, USA

IJERPH, 2020, vol. 17, issue 2, 1-10

Abstract: There are little epidemiological data on the impact of persistent organic pollutants (POPs) and endocrine disruptors on mammographic density (MD), a strong predictor of breast cancer. We assessed MD in 116 non-Hispanic white post-menopausal women for whom serum concentrations of 23 commonly detected chemicals including 3 polybrominated diphenyl ethers (PBDEs), 8 per- and polyfluoroalkyl substances (PFASs), and 12 polychlorinated biphenyls (PCBs) had been measured. Linear regression analyses adjusting for potential confounders were used to examine the associations between the levels of the chemical compounds, modeled as continuous and dichotomized (above/below median) variables, and square-root-transformed MD. None of the associations were statistically significant after correcting for multiple testing. Prior to correction for multiple testing, all chemicals with un-corrected p- values < 0.05 had regression coefficients less than zero, suggesting inverse associations between increased levels and MD, if any. The smallest p- value was observed for PCB-153 (regression coefficient for above-median vs. below-median levels: −0.87, un-corrected p = 0.008). Neither parity nor body mass index modified the associations. Our results do not support an association between higher MD and serum levels of PBDEs, PCBs, or PFASs commonly detected in postmenopausal women.

Keywords: persistent organic pollutants; mammographic density; per- and polyfluoroalkyl substances; polybrominated diphenyl ethers; polychlorinated biphenyls (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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