Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke

Yi-Ju Tseng, Ru-Fang Hu, Shin-Tyng Lee, Yu-Li Lin, Chien-Lung Hsu, Shih-Wei Lin, Chia-Wei Liou, Jiann- Der Lee, Tsung-I Peng and Tsong-Hai Lee
Additional contact information
Yi-Ju Tseng: Department of Information Management, Chang Gung University, Taoyuan 33302, Taiwan
Ru-Fang Hu: Department of Information Management, Chang Gung University, Taoyuan 33302, Taiwan
Shin-Tyng Lee: Department of Information Management, Chang Gung University, Taoyuan 33302, Taiwan
Yu-Li Lin: Department of Nursing, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan
Chien-Lung Hsu: Department of Information Management, Chang Gung University, Taoyuan 33302, Taiwan
Shih-Wei Lin: Department of Information Management, Chang Gung University, Taoyuan 33302, Taiwan
Chia-Wei Liou: Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
Jiann- Der Lee: College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Tsung-I Peng: College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
Tsong-Hai Lee: Stroke Center and Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

IJERPH, 2020, vol. 17, issue 2, 1-12

Abstract: Ischemic stroke is the most common type of stroke, and early interventional treatment is associated with favorable outcomes. In the guidelines, thrombolytic therapy using recombinant tissue-type plasminogen activator (rt-PA) is recommended for eligible patients with acute ischemic stroke. However, the risk of hemorrhagic complications limits the use of rt-PA, and the risk factors for poor treatment outcomes need to be identified. To identify the risk factors associated with in-hospital poor outcomes in patients treated with rt-PA, we analyzed the electronic medical records of patients who were diagnosed with acute ischemic stroke and treated for rt-PA at Chang Gung Memorial Hospitals from 2006 to 2016. In-hospital death, intensive care unit (ICU) stay, or prolonged hospitalization were defined as unfavorable treatment outcomes. Medical history variables and laboratory test results were considered variables of interest to determine risk factors. Among 643 eligible patients, 537 (83.5%) and 106 (16.5%) patients had favorable and poor outcomes, respectively. In the multivariable analysis, risk factors associated with poor outcomes were female gender, higher stroke severity index (SSI), higher serum glucose levels, lower mean corpuscular hemoglobin concentration (MCHC), lower platelet counts, and anemia. The risk factors found in this research could help us study the treatment strategy for ischemic stroke.

Keywords: ischemic stroke; risk factor; thrombolytic therapy; rt-PA; outcome analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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