Evaluation of the Oxidative Stress Status in Zebrafish ( Danio rerio ) Liver Induced by Three Typical Organic UV Filters (BP-4, PABA and PBSA)

Xinxin Huang, Yuanyuan Li, Tantan Wang, Hui Liu, Jiaqi Shi and Xuesheng Zhang
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Xinxin Huang: School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China
Yuanyuan Li: School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China
Tantan Wang: School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China
Hui Liu: College of Biological and Chemical Engineering, Jiaxing University, Jiaxing 314001, Zhejiang, China
Jiaqi Shi: Nanjing Institute of Environmental Sciences of the Ministry of Environmental Protection, Nanjing 210042, Jiangsu, China
Xuesheng Zhang: School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China

IJERPH, 2020, vol. 17, issue 2, 1-13

Abstract: Organic UV filters are a kind of emerging pollutants, which have been widely used in personal care products (PCPs). This study evaluated the effects of benzophenone-4 (BP-4), 4-aminobenzoic acid (PABA), and 2-phenylbenzimidazole-5-sulfonic acid (PBSA) on the selected indices of antioxidative responses in zebrafish ( Danio rerio ) liver. Zebrafish were exposed to two different doses (i.e., 0.5 and 5 mg L −1 ) of semi-static water with three individual compounds. Liver samples were collected on 7 and 14 days to analyze biochemical indicators, including superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH), and malondialdehyde (MDA). Oxidative stress occurred in zebrafish liver with significantly changed indicators during the whole exposure period. Different experimental groups could induce or inhibit the activity of antioxidant enzymes with varying degrees. With a prolonged exposure time and increased exposure dose, the hepatic lipid peroxidation was also obviously observed. Moreover, the toxicity order of three organic UV filters was analyzed using the integrated biomarker response (IBR) index and the results indicate that exposure to PABA for 7 days at 0.5 mg L −1 and PBSA for 7 days at 5 mg L −1 induced the most severe oxidative stress in the liver of zebrafish.

Keywords: organic UV filters; oxidative stress; lipid peroxidation; integrated biomarker response; zebrafish (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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