Supplementation with a Bioactive Melon Concentrate in Humans and Animals: Prevention of Oxidative Damages and Fatigue in the Context of a Moderate or Eccentric Physical Activity

Marion Saby, Audrey Gauthier, Sandy Barial, Laure Egoumenides and Bernard Jover
Additional contact information
Marion Saby: EA7288 UFR Pharmacie, Université de Montpellier, CEDEX 5, 34093 Montpellier, France
Audrey Gauthier: Bionov Research, 939 rue de la croix verte, 34090 Montpellier, France
Sandy Barial: EA7288 UFR Pharmacie, Université de Montpellier, CEDEX 5, 34093 Montpellier, France
Laure Egoumenides: Bionov Research, 939 rue de la croix verte, 34090 Montpellier, France
Bernard Jover: PhyMedExp, INSERM CNRS, Université de Montpellier, IURC, CEDEX 5, 34295 Montpellier, France

IJERPH, 2020, vol. 17, issue 4, 1-17

Abstract: Exercise is recognized to provide both physical and psychological health benefits. However, oxidative stress can occur and induce muscular damages. SOD B ® ; M is a melon concentrate, well known to counteract oxidative stress and prevent its side effects. The present study aimed to evaluate the potential of the melon concentrate in the context of both a strong and isolated effort associated with deleterious effects, and a moderate and regular physical activity considered as beneficial. First, a preclinical study was set up on rats to evaluate its potential on the prevention of damages induced by an eccentric exercise. Secondly, the combined effect of the melon concentrate and a regular standardized physical training was studied on the overall physical condition of healthy subjects in a randomized, double-blind, placebo-controlled trial. Repeated measures Analysis of Variance (ANOVA), student’s t test and Mann–Whitney test were used for statistical analyses. Melon concentrate helped to prevent gastrocnemius damages induced by the eccentric exercise. It allowed a reduction of fibrosis by approximately 38% and a reduction of Tumor Necrosis Factor- α (TNF-α) plasma level by 28%. This supplementation also induced a rearrangement of myosin fibers and an increase in PGC-1α plasma level. In the clinical study, melon concentrate was able to decrease oxidative stress and C-Reactive protein (CRP) plasma level. Besides, magnesium (Mg) plasma level was higher in the context of a regular training performed by healthy subjects supplemented with the melon concentrate. Therefore, the melon concentrate allowed a better adaptation to effort linked to PGC-1α activation: a regulator of energy metabolism. The antioxidant properties of the melon concentrate and its ability to mobilize magnesium also suggest that the supplementation could induce a better resistance to fatigue and recovery during regular physical activity.

Keywords: physical activity; oxidative stress; superoxide dismutase; eccentric exercise; melon concentrate; fatigue; PGC-1?; magnesium (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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