Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study

Francisco M. Peinado, Inmaculada Lendínez, Rafael Sotelo, Luz M. Iribarne-Durán, Jorge Fernández-Parra, Fernando Vela-Soria, Nicolás Olea, Mariana F. Fernández, Carmen Freire, Josefa León, Beatriz Pérez-Cabrera, Olga Ocón-Hernández and Francisco Artacho-Cordón
Additional contact information
Francisco M. Peinado: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Inmaculada Lendínez: General Surgery, San Cecilio University Hospital, E-18016 Granada, Spain
Rafael Sotelo: Gynaecology and Obstetrics Unit, ‘San Cecilio’ University Hospital, E-18016 Granada, Spain
Luz M. Iribarne-Durán: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Jorge Fernández-Parra: Gynaecology and Obstetrics Unit, ‘Virgen de las Nieves’ University Hospital, E-18014 Granada, Spain
Fernando Vela-Soria: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Nicolás Olea: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Mariana F. Fernández: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Carmen Freire: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Josefa León: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Beatriz Pérez-Cabrera: General Surgery, San Cecilio University Hospital, E-18016 Granada, Spain
Olga Ocón-Hernández: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain
Francisco Artacho-Cordón: Instituto de Investigación Biosanitaria ibs, E-18012 Granada, Spain

IJERPH, 2020, vol. 17, issue 4, 1-13

Abstract: Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Methods : This case–control study enrolled 124 women between January 2018 and July 2019: 35 women with endometriosis (cases) and 89 women without endometriosis undergoing abdominal surgery for other reasons (controls). Endometriosis was diagnosed (cases) or ruled out (controls) by laparoscopic inspection of the pelvis and the biopsy of suspected lesions (histological diagnosis). Fasting urine samples were collected before surgery to determine concentrations of BPA, BPS, BPF, and TBARS. Associations of bisphenol and TBARS concentrations with endometriosis risk were explored with multivariate logistic and linear regression analyses. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Σbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Σbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Σbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 μM). Conclusion : Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings.

Keywords: bisphenol A; bisphenol F; bisphenol S; endocrine disruption; endometriosis; oxidative stress (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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