Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Lecidamia Cristina Leite Damascena, Nyellisonn Nando Nóbrega de Lucena, Isabella Lima Arrais Ribeiro, Tarciana Liberal Pereira, Luiz Medeiros Araújo Lima-Filho and Ana Maria Gondim Valença
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Lecidamia Cristina Leite Damascena: Departament of Statistics, Federal University of Paraíba (UFPB), João Pessoa, PB 58051-900, Brazil
Nyellisonn Nando Nóbrega de Lucena: Departament of Statistics, Federal University of Paraíba (UFPB), João Pessoa, PB 58051-900, Brazil
Isabella Lima Arrais Ribeiro: Departament of Public Health, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049-900, Brazil
Tarciana Liberal Pereira: Departament of Statistics, Federal University of Paraíba (UFPB), João Pessoa, PB 58051-900, Brazil
Luiz Medeiros Araújo Lima-Filho: Departament of Statistics, Federal University of Paraíba (UFPB), João Pessoa, PB 58051-900, Brazil
Ana Maria Gondim Valença: Departament of Statistics, Federal University of Paraíba (UFPB), João Pessoa, PB 58051-900, Brazil

IJERPH, 2020, vol. 17, issue 4, 1-12

Abstract: This paper investigates the occurrence of severe oral mucositis and associated factors in blood and solid cancer pediatric patients subjected to cancer treatment, using a survival analysis. A longitudinal, descriptive, observational and inductive study of 142 pediatric patients aged from 0 to 19 years was conducted from 2013 to 2017. Data were collected using a form to record the sociodemographic characteristics and health-related aspects of patients and the modified Oral Assessment Guide (OAG). Survival analysis was performed using the Kaplan–Meier method and Cox semiparametric model. The median times to occurrence of severe oral mucositis were 35.3 and 77.1 days for patients with hematologic malignancies and solid tumors, respectively. The Cox model showed that white cell changes and platelet counts as well as the use of natural chemotherapeutic agents are risk factors for the occurrence of oral mucositis among patients with hematologic malignancies. Nonetheless, among patients with solid tumors, the occurrence of oral mucositis was associated with female sex, mixed ethnicity, the presence of metastasis, abnormal creatinine levels, a combination of chemotherapy, radiotherapy, and surgery, and the administration of chemotherapeutic agents included in the miscellaneous group. The time to occurrence of severe oral mucositis and its associated factors varied according to cancer type.

Keywords: oral mucositis; cancer; child; survival analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:4:p:1235-:d:320704

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