Determination of Propane-1,3-sultone in Workplace Air for Occupational Exposure Assessment

Anna Jeżewska
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Anna Jeżewska: Central Institute for Labour Protection—National Research Institute, Czerniakowska 16, 00-701 Warsaw, Poland

IJERPH, 2020, vol. 17, issue 4, 1-9

Abstract: Propane-1,3-sultone (PS) is an alkylating substance used in the production of polymers, fungicides, insecticides, dyes, and detergents. It is absorbed into the human body by inhalation, digestion, and through the skin; it is also a possible carcinogen. Occupational exposure to this substance may occur on industrial or laboratory contact. In Poland, the maximum allowable concentration (MAC) for PS in workplace air is 7 µg/m 3 . The paper presents a method for determination of PS in workplace air using a gas chromatograph coupled with a mass spectrometer (GC-MS). Air containing PS is passed through a glass tube containing a glass fiber filter and two layers of silica gel. The substance is washed with acetonitrile and the solution obtained analysed using GC-MS. The measuring range for an air sample of 360 L is 0.7 ÷ 14 µg/m 3 . The limit of detection (LOD) is 13 ng/m 3 , limit of quantification (LOQ) is 40 ng/m 3 .

Keywords: 1,2-oxathiolane 2,2-dioxide; carcinogen; air pollution; workplace air; occupational exsure; chromatography; health sciences; environmental engineering (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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