Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review

Marco Capece, Massimiliano Creta, Armando Calogero, Roberto La Rocca, Luigi Napolitano, Biagio Barone, Antonello Sica, Ferdinando Fusco, Michele Santangelo, Concetta Dodaro, Caterina Sagnelli, Nicola Carlomagno, Felice Crocetto, Gianluigi Califano, Francesco Mangiapia and Nicola Longo
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Marco Capece: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Massimiliano Creta: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Armando Calogero: Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Roberto La Rocca: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Luigi Napolitano: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Biagio Barone: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Antonello Sica: Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
Ferdinando Fusco: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Michele Santangelo: Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Concetta Dodaro: Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Caterina Sagnelli: Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
Nicola Carlomagno: Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy
Felice Crocetto: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Gianluigi Califano: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Francesco Mangiapia: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy
Nicola Longo: Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples “Federico II”, 80131 Naples, Italy

IJERPH, 2020, vol. 17, issue 4, 1-9

Abstract: Background : Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods : We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results : Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa risk, improved PCa-related survival, improved functional outcomes, and reduced ADT-related adverse events.

Keywords: prostate cancer; elderly; physical activity; cancer prevention; adjuvant treatment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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