Parameters of Oxidative Stress in Reproductive and Postmenopausal Mexican Women

Araceli Montoya-Estrada, Karla Guadalupe Velázquez-Yescas, Daniela Belen Veruete-Bedolla, José David Ruiz-Herrera, Alma Villarreal-Barranca, José Romo-Yañez, Guillermo Federico Ortiz-Luna, Arturo Arellano-Eguiluz, Mario Solis-Paredes, Arturo Flores-Pliego, Aurora Espejel-Nuñez, Guadalupe Estrada-Gutierrez and Enrique Reyes-Muñoz
Additional contact information
Araceli Montoya-Estrada: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Karla Guadalupe Velázquez-Yescas: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Daniela Belen Veruete-Bedolla: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
José David Ruiz-Herrera: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Alma Villarreal-Barranca: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
José Romo-Yañez: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Guillermo Federico Ortiz-Luna: Peri and Postmenopause Clinic. National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Arturo Arellano-Eguiluz: Peri and Postmenopause Clinic. National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Mario Solis-Paredes: Department of Human Genetics and Genomics, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Arturo Flores-Pliego: Department of Immunobiochemistry, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Aurora Espejel-Nuñez: Department of Immunobiochemistry, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Guadalupe Estrada-Gutierrez: Direction of Research, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico
Enrique Reyes-Muñoz: Coordination of Gynecological and Perinatal Endocrinology, National Institute of Perinatology, Ministry of Health, México City 11000, Mexico

IJERPH, 2020, vol. 17, issue 5, 1-11

Abstract: In the reproductive phase, women experience cyclic changes in the ovaries and uterus, and hormones regulate these changes. Menopause is the permanent loss of menstruation after 12 months of amenorrhea. Menopause is also linked to a decrease in estrogen production, causing an imbalance in oxidative stress. We aimed to compare the three stages of lipid peroxidation, protein oxidative damage, and total antioxidant capacity (TAC) between reproductive-aged women (RAW) and postmenopausal women (PMW) in Mexico. We carried out a cross-sectional study with 84 women from Mexico City, including 40 RAW and 44 PMW. To determine the oxidative stress of the participants, several markers of lipid damage were measured: dienes conjugates (DC), lipohydroperoxides (LHP), and malondialdehyde (MDA); exposure to protein carbonyl is indicative of oxidative modified proteins, and TAC is indicative of the antioxidant defense system. Biomarkers of oxidative stress were significantly lower in RAW vs. PMW. DC were 1.31 ± 0.65 vs. 1.7 ± 0.51 pmol DC/mg dry weight ( p = 0.0032); LHP were 4.95 ± 2.20 vs. 11.30 ± 4.24 pmol LHP/mg dry weight ( p < 0.0001); malondialdehyde was 20.37 ± 8.20 vs. 26.10 ± 8.71 pmol MDA/mg dry weight ( p = 0.0030); exposure of protein carbonyl was 3954 ± 884 vs. 4552 ± 1445 pmol PC/mg protein ( p = 0.042); and TAC was 7244 ± 1512 vs. 8099 ± 1931 pmol Trolox equivalent/mg protein ( p = 0.027). PMW display significantly higher oxidative stress markers compared to RAW; likewise, PMW show a higher TAC.

Keywords: reactive oxygen species; postmenopause; protein damage; total antioxidant capacity; malondialdehyde (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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