Quercetin and Its Mixture Increase the Stress Resistance of Caenorhabditis elegans to UV-B

Shi-ming Li, Dan Liu, Yi-lin Liu, Bin Liu and Xing-huang Chen
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Shi-ming Li: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Dan Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Yi-lin Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Bin Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Xing-huang Chen: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China

IJERPH, 2020, vol. 17, issue 5, 1-13

Abstract: Ultraviolet B (UV-B, 280–320 nm) radiation causes complex molecular reactions in cells, including DNA damage, oxidative stress, and apoptosis. This study designed a mixture consisting of quercetin, luteolin and lycopene and used Caenorhabditis elegans as a model to study the resistance of these natural chemicals to UV-B. Specifically, we have confirmed that quercetin and its mixture can increase the resistance of Caenorhabditis elegans to UV-B through lifespan test, reactive oxygen species level assay, germ cell apoptosis test, embryonic lethal test and RT-qPCR experiments. The results show that quercetin and its mixture prolonged the lifespan of UV-B-irradiated Caenorhabditis elegans and reduced abnormal levels of reactive oxygen species, embryo death, and apoptosis induced by UV-B. The protective effect of quercetin and its mixture may be attributed to its down-regulation of HUS-1 , CEP-1 , EGL-1 and CED-13. Therefore, the results of this research could help the development of UV-B radiation protection agents.

Keywords: Caenorhabditis elegans; UV-B; quercetin; luteolin; lycopene; apoptosis; stress resistance (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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