Long-Term Fipronil Treatment Induces Hyperactivity in Female Mice

Svenja Koslowski, Camille Latapy, Pierrïck Auvray, Marc Blondel and Laurent Meijer
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Svenja Koslowski: Perha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, France
Camille Latapy: C.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, France
Pierrïck Auvray: C.RIS Pharma, Parc Technopolitain, Atalante Saint Malo, 35400 Saint Malo, France
Marc Blondel: Université Brest, Inserm, EFS, UMR1078, GGB, F-29200 Brest, France
Laurent Meijer: Perha Pharmaceuticals & ManRos Therapeutics, Centre de Perharidy, 29680 Roscoff, Bretagne, France

IJERPH, 2020, vol. 17, issue 5, 1-22

Abstract: Fipronil is an insecticide widely used for veterinary and agricultural purposes. While its insecticidal properties mostly rely on its high affinity antagonistic activity on insect γ aminobutyric acid (GABA) receptors, fipronil and its main metabolite fipronil sulfone nevertheless display non-negligible affinity for mammalian GABA A receptor. As several environmental toxicants have been shown to raise the risk of developing various neurodegenerative disorders, the aim of this study was to evaluate whether long-term low dose administration of fipronil could lead to cognitive deficiencies. Our results indicate that long-term fipronil treatment leads to behavioral perturbations in mice, indicating an accumulative effect of sustained exposure to low dose of fipronil. Although no memory impairment was observed during the course of our study, we noticed a significant hyperlocomotion behavior after 43 weeks of weekly fipronil administration, which is consistent with its direct effect on the GABAergic system.

Keywords: fipronil; hyperlocomotion; memory impairment; dementia; insecticide (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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