Evaluation of Vitamin D Fractions in Obese Hypertensive Patients

Marta Pelczyńska, Teresa Grzelak, Marcelina Sperling, Matylda Kręgielska-Narożna, Paweł Bogdański and Krystyna Czyżewska
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Marta Pelczyńska: Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 84 St., 60-569 Poznan, Poland
Teresa Grzelak: Department and Division of Physiology, Poznan University of Medical Sciences, Swiecickiego 6 St., 60-781 Poznan, Poland
Marcelina Sperling: Division of Biology of Civilization-Linked Diseases, Poznan University of Medical Sciences, Swiecickiego 6 St., 60-781 Poznan, Poland
Matylda Kręgielska-Narożna: Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 84 St., 60-569 Poznan, Poland
Paweł Bogdański: Department of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego 84 St., 60-569 Poznan, Poland
Krystyna Czyżewska: Stanisław Staszic University of Applied Sciences in Pila, Podchorazych 10 St., 64-920 Pila, Poland

IJERPH, 2020, vol. 17, issue 5, 1-12

Abstract: Vitamin D fractions can be involved in the pathogenesis of metabolic disorders, but their concentrations are rarely determined. The aim of this study was to evaluate the concentration of vitamin D fractions in obese hypertensive patients and to determine its associations with anthropometric parameters, glucose levels, and lipid profiles. A total of 85 obese hypertensive patients (OBHT) and 40 nonobese nonhypertensive subjects (NOBNHT) underwent biochemical measurements of lipid profiles, glycemia, 25-hydroxyvitamin D (25(OH)D), free vitamin D (free25(OH)D), vitamin D binding protein, albumin levels. Moreover, free25(OH)D and bioavailable25(OH)D (bio25(OH)D) concentrations were calculated. Blood pressure and anthropometric measurements were performed. Differences between groups ( p < 0.001) were found for 25(OH)D (OBHT 40.25 ± 18.02 vs. NOBNHT 64.10 ± 22.29 nmol/L), free25(OH)D (9.77 (7.46; 11.49) vs. 13.80 (10.34; 16.82) pmol/L), bioavailable 25(OH)D (3.7 (2.8; 4.4) vs. 5.4 (4.2; 6.7) nmol/L), and calculated free25(OH)D (7.82 (5.54; 11.64) vs. 10.46(8.06;16.28) pmol/L, p = 0.002). The OBHT patients showed no relationship between vitamin D fractions concentration and glucose or lipids level, although it was associated with anthropometric parameters. In the NOBNHT group, vitamin D fractions correlated positively with HDL cholesterol and negatively with triglyceridemia and hip circumference. Vitamin D fractions were decreased in obese hypertensive subjects, and were associated with anthropometric parameters, but not with glucose level or lipid profiles; they thus cannot be considered as a predictive marker of metabolic disorders in this group of patients.

Keywords: vitamin D; free vitamin D; bioavailable vitamin D; obesity; hypertension (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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