Neutrophil-To-Lymphocyte and Platelet-To-Lymphocyte Ratios as Prognostic Markers of Survival in Patients with Head and Neck Tumours—Results of a Retrospective Multicentric Study

Zsuzsanna Szilasi, Valéria Jósa, Zsombor Zrubka, Tünde Mezei, Tamás Vass, Keresztély Merkel, Frigyes Helfferich and Zsolt Baranyai
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Zsuzsanna Szilasi: Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, H-1134 Budapest, Hungary
Valéria Jósa: Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc Hospital, H-1204 Budapest, Hungary
Zsombor Zrubka: Department of Health Economics, Corvinus University of Budapest, H-1093 Budapest, Hungary
Tünde Mezei: Department of Urology, Jahn Ferenc Hospital, H-1204 Budapest, Hungary
Tamás Vass: Department of Surgery, Szent Imre Hospital, H-1115 Budapest, Hungary
Keresztély Merkel: Department of Surgery, Szent Imre Hospital, H-1115 Budapest, Hungary
Frigyes Helfferich: Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, H-1134 Budapest, Hungary
Zsolt Baranyai: 1st Department of Surgery, Semmelweis University, H-1082 Budapest, Hungary

IJERPH, 2020, vol. 17, issue 5, 1-12

Abstract: Background: The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients. Methods: Clinical data of 156 patients managed for HNSCC at two head and neck surgery centres were analyzed retrospectively. We studied the relationships between survival and PLR as well as NLR. Results: With regards to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant ( p = 0.004), and we found the same for disease-free survival ( p = 0.05), and tumour-specific mortality ( p = 0.009). Concerning NLR, the difference in tumour-specific survival was statistically significant ( p = 0.006). According to the multivariate analysis, NLR values higher than the threshold indicated an enhanced risk for overall as well as for tumour-specific mortality. Conclusion: In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival.

Keywords: head and neck neoplasms; survival; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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