Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

Yumjirmaa Mandakh, Ralf Rittner, Erin Flanagan, Anna Oudin, Christina Isaxon, Mary Familari, Stefan Rocco Hansson and Ebba Malmqvist
Additional contact information
Yumjirmaa Mandakh: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden
Ralf Rittner: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden
Erin Flanagan: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden
Anna Oudin: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden
Christina Isaxon: Department of Ergonomics and Aerosol Technology, Lund University, Sölvegatan 26, Box 118, 22100 Lund, Sweden
Mary Familari: School of BioSciences, University of Melbourne, Parkville, Melbourne 3010, Australia
Stefan Rocco Hansson: Division of Obstetrics and Gynecology, Department of Clinical Sciences, Lund University, Klinikgatan 12, 22185 Lund, Sweden
Ebba Malmqvist: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden

IJERPH, 2020, vol. 17, issue 5, 1-16

Abstract: The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM 2.5 and PM 10 ), and NO X at the maternal residential address estimated by Gaussian dispersion modeling from 2000 to 2009. Analyses were conducted using binary logistic regression. A subtype analysis for small-for-gestational age (SGA) was performed. All analyses were adjusted for obstetrical risk factors and socioeconomic predictors. There were 1286 (2.9%) PE cases in the analysis. An adjusted odds ratio (AOR) of 1.35 with a 95% confidence interval (CI) of 1.11–1.63 was found when comparing the lowest quartile of BC exposure to the highest quartile in the third trimester The AOR for PE associated with each 5 µg/m 3 increase in locally emitted PM 2.5 was 2.74 (95% CI: 1.68, 4.47) in the entire pregnancy. Similar patterns were observed for each 5 µg/m 3 increment in locally emitted PM 10 . In pregnancies complicated by PE with SGA, the corresponding AOR for linear increases in BC was 3.48 (95% CI: 1.67, 7.27). In this low-level setting, maternal exposure to ambient air pollution during gestation was associated with the risk of developing PE. The associations seemed more pronounced in pregnancies with SGA complications, a finding that should be investigated further.

Keywords: Ambient air pollution; preeclampsia; small-for-gestational age; environmental epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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