Lower Serum Fibroblast Growth Factor 21 Levels are Associated with Normal Lumbar Spine Bone Mineral Density in Hemodialysis Patients

Yin-Ting Wu, Bang-Gee Hsu, Chih-Hsien Wang, Yu-Li Lin, Yu-Hsien Lai and Chiu-Huang Kuo
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Yin-Ting Wu: School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Bang-Gee Hsu: School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Chih-Hsien Wang: School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Yu-Li Lin: School of Medicine, Tzu-Chi University, Hualien 970, Taiwan
Yu-Hsien Lai: Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan
Chiu-Huang Kuo: Division of Nephrology, Buddhist Tzu-Chi General Hospital, Hualien 970, Taiwan

IJERPH, 2020, vol. 17, issue 6, 1-8

Abstract: Recent evidence has indicated that fibroblast growth factor 21 (FGF21) regulates longitudinal bone growth, with increased FGF21 levels leading to bone loss. The present study evaluated the relationship between bone mineral density (BMD) and serum FGF21 levels in patients undergoing hemodialysis (HD). We analyzed blood samples from 95 patients undergoing HD and measured BMD using dual-energy X-ray absorptiometry of the lumbar vertebrae (L2–L4). Serum FGF21 concentrations were determined using a commercially available enzyme-linked immunosorbent assay kit. Thirteen (11.6%) patients were found to have osteoporosis, 27 (28.4%) osteopenia, and 57 patients had normal BMD. Advanced age and decreased body mass index, height, body weight, waist circumference, and triglyceride level were associated with lower lumbar T-scores, as were increased alkaline phosphatase, urea reduction rate, fractional clearance index for urea, and FGF21 levels. Low log-FGF21, increased body mass index, increased pre-HD body weight, and increased logarithmically transformed triglycerides (log-TG) were found to be significantly and independently associated with lumbar BMD by multivariate forward stepwise linear regression analysis with adjustment for significant confounders. We conclude that high serum FGF21 level is negatively associated with BMD in patients undergoing HD.

Keywords: bone mineral density; fibroblast growth factor 21; hemodialysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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Citations: View citations in EconPapers (1)

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