Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1? Pathway

Jia Luo, Changfa Tang, Xiaobin Chen, Zhanbing Ren, Honglin Qu, Rong Chen and Zhen Tong
Additional contact information
Jia Luo: Key Laboratory of Kinesiology Evaluation and Recovery of General Administration of Sport of China, Sports Science institute of Hunan, Changsha 410012, China
Changfa Tang: Department of Physical Education, Hunan Normal University, Changsha 410012, China
Xiaobin Chen: Department of Sports and Health, Guangzhou Sport University, Guangzhou 510500, China
Zhanbing Ren: Department of Physical Education, Shenzhen University, Shenzhen 518060, China
Honglin Qu: Department of Physical Education, Yichun College, Yichun 336000, China
Rong Chen: Department of Physical Education, Hunan Normal University, Changsha 410012, China
Zhen Tong: Department of Physical Education, Hunan Normal University, Changsha 410012, China

IJERPH, 2020, vol. 17, issue 6, 1-12

Abstract: This study was to study the impact of aerobic exercises on the chronic unpredictable mild stress (CUMS) in mice, and to discuss the possible mechanism from the skeletal muscle AMPK/PGC-1α energy metabolism signaling pathway. The healthy male mice were randomly divided into Control Group (CG), Model Group (MG), and Model Exercise Group (ME).Twelve stress methods were adopted for four weeks (28 days) to establish the depression model. ME was subject to aerobic training plan after the model was established. The weight of the mice was recorded weekly. After the experimental intervention, the three groups of mice were subjected to behavioral assessment tests. Western blotting, RT-PCR, and ELISA were performed to test AMPK, p-AMPK, PGC-1α, and ATP in skeletal muscle. There were no significant difference in body weight between the three groups. CUMS leaded to significant decline in behavioral scores. and the p-AMPK and PGC-1α decreased significantly. But boosted ATP content. Aerobic exercise enhanced the expressions of p-AMPK and PGC-1α, increased the ratio of p-AMPK/AMPK, boosted ATP content. And improved behavioral scores significantly. Chronic stress-induced depression-like behavior was improved significantly by Aerobic exercise. The mechanism of aerobic exercise for improving depressive symptoms in mice with chronic stress depression may be related to influence AMPK/PGC-1α pathway.

Keywords: depression; chronic stress; AMPK/PGC-1?; exercise (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/6/2042/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/6/2042/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:6:p:2042-:d:334387

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().