Qualitative Phenotyping of Obstructive Sleep Apnea and Its Clinical Usefulness for the Sleep Specialist

Marcello Bosi, Andrea De Vito, Danny Eckert, Joerg Steier, Bhik Kotecha, Claudio Vicini and Venerino Poletti
Additional contact information
Marcello Bosi: Pulmonary Operative Unit, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Romagna Health Company, 47121 Forlì, Italy
Andrea De Vito: Head & Neck Department, Ear Nose Throat (ENT) Unit, Santa Maria delle Croci Hospital, Romagna Health Company, 48121 Ravenna, Italy
Danny Eckert: Adelaide Institute for Sleep Health, A. Flinders University. Centre of Research Excellence, Adelaide 5049, Australia
Joerg Steier: Lane Fox Unit/Sleep Disorders Centre, Guy’s & St Thomas’ National Health Service (NHS) Foundation Trust, London SE19RT, UK
Bhik Kotecha: Nuffield Health Brentwood, Shenfield Road, Brentwood, Essex CM15 8EH, UK
Claudio Vicini: Head & Neck Department, ENT & Oral Surgery Unit, Morgagni-Pierantoni/Infermi Hospital, Romagna Health Company, 47121 Forlì, Italy
Venerino Poletti: Pulmonary Operative Unit, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Romagna Health Company, 47121 Forlì, Italy

IJERPH, 2020, vol. 17, issue 6, 1-15

Abstract: Introduction: The anatomical collapsibility of the upper airway, neuromuscular tone and function, sleep–wake and ventilatory control instability, and the arousal threshold all interact and contribute to certain pathophysiologic features that characterize different types of obstructive sleep apnea (OSA). A model of qualitative phenotypizationallowsus to characterize the different pathophysiological traits in OSA patients.Methods: A narrative review was performed, to analyze the available literature evidence, with the purpose of generating a model of qualitative phenotypization to characterize pathophysiological traits in patients with OSA.Results: 96 out of 3829 abstracts were selected for full-text review. Qualitative phenotyping model of OSA:Data concerning the OSA qualitative pathophysiological traits’ measurement can be deducted by means of clinical PSG, grade of OSA severity, and therapeutic level of Continuous Positive Airway Pressure (CPAP) and are reported in the text. This approach would allow qualitative phenotyping with widely accessible methodology in a routine clinical scenario and is of particular interest for the sleep specialist, surgical treatment decision-making, and customized OSA multimodality treatment.

Keywords: obstructive sleep apnea; phenotypization; CPAP; pathophysiological traits (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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