Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Elise Goetschalckx, Djalila Mekahli, Elena Levtchenko and Karel Allegaert
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Elise Goetschalckx: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
Djalila Mekahli: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
Elena Levtchenko: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium
Karel Allegaert: Department of Development and Regeneration, KU Leuven, Herestraat 49, 3000 Leuven, Belgium

IJERPH, 2020, vol. 17, issue 6, 1-8

Abstract: Various cohort studies document a lower glomerular filtration rate (GFR) in former extremely low birth weight (ELBW, <1000 g) neonates throughout childhood when compared to term controls. The current aim is to pool these studies to describe the GFR pattern over the pediatric age range. To do so, we conducted a systematic review on studies reporting on GFR measurements in former ELBW cases while GFR data of healthy age-matched controls included in these studies were co-collected. Based on 248 hits, 6 case-control and 3 cohort studies were identified, with 444 GFR measurements in 380 former ELBW cases (median age 5.3–20.7 years). The majority were small (17–78 cases) single center studies, with heterogeneity in GFR measurement (inulin, cystatin C or creatinine estimated GFR formulae) tools. Despite this, the median GFR (mL/min/1.73 m 2 ) within case-control studies was consistently lower (−13%, range −8% to −25%) in cases, so that a relevant minority (15–30%) has a eGFR<90 mL/min/1.73 m 2 ). Consequently, this pooled analysis describes a consistent pattern of reduced eGFR in former ELBW cases throughout childhood. Research should focus on perinatal risk factors for impaired GFR and long-term outcome, but is hampered by single center cohorts, study size and heterogeneity of GFR assessment tools.

Keywords: glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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