Environmental Monitoring of PAHs Exposure, Biomarkers and Vital Status in Coke Oven Workers

Luigi Vimercati, Lucia Bisceglia, Domenica Cavone, Antonio Caputi, Luigi De Maria, Maria Celeste Delfino, Vincenzo Corrado and Giovanni Maria Ferri
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Luigi Vimercati: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Lucia Bisceglia: Strategic Regional Health and Social Agency of Puglia (AReS Puglia), 52 G. Gentile Street, 70126 Bari, Italy
Domenica Cavone: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Antonio Caputi: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Luigi De Maria: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Maria Celeste Delfino: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Vincenzo Corrado: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy
Giovanni Maria Ferri: Interdisciplinary Department of Medicine, Occupational Medicine “B. Ramazzini”, University of Bari Medical School, 11 G. Cesare Square, 70124 Bari, Italy

IJERPH, 2020, vol. 17, issue 7, 1-33

Abstract: A follow-up study of a cohort of workers from a coke plant compared with a control group from the same industrial area was conducted in 2019. The recruitment and environmental and biomarker measurements were performed during 1993/1994. The environmental concentrations of polycyclic aromatic hydrocarbons (PAH), B(a)P, pyrene and nitro-PAH were measured. Personal data were collected via an individual semi-structured questionnaire by a trained physician. All biomarkers were measured after a specific blood drawing for every test. Significant risks (ORs) were observed for nitro-PAH ( ≥ 0.12 µg/m 3 ) [OR = 7.96 (1.01–62.82)], urinary 1-hydroxypyrene (1-OHpy) (≥0.99 µmoles/moles of creatinine) [OR = 11.71 (1.47–92.90)], PAH DNA adducts (P 32 ) (≥2.69 adducts/10 8 nucleotides) [OR = 5.46 (1.17–25.58)], total nitro-PAH hemoglobin adducts (≥161.68 fg/µg of Hb) [OR = 5.92 (1.26–27.86)], sister chromatid exchange (SCE) with TCR (≥377.84 SCE/cell chromosomes) [OR = 13.06 (3.95–93.10)], sister chromatid exchange with T (≥394.72 total SCE) [OR = 13.06 (3.95–93.10)], and sister chromatid exchange with X (≥8.19 mean SCE) [OR = 13.06 (3.95–93.10)]. Significant risk of death for all causes and chromosomal aberrations (48 h) (OR = 7.19 [1.19–43.44]) or micronuclei in culture at 48 h (OR = 3.86 [1.04–14.38]) were also found.

Keywords: cohort; coke plant; biomarkers; vital status; occupational exposure; sister chromatid exchange; urinary 1-hydroxypyrene (1-OHpy), PAH DNA adducts; total nitro-PAH hemoglobin adducts (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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