Alpha-1-Antitrypsin Deficiency and Bronchiectasis: A Concomitance or a Real Association?

Alessandro Sanduzzi, Emanuele Ciasullo, Ludovica Capitelli, Stefano Sanduzzi Zamparelli and Marialuisa Bocchino
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Alessandro Sanduzzi: Department of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy
Emanuele Ciasullo: Department of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy
Ludovica Capitelli: Department of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy
Stefano Sanduzzi Zamparelli: University Luigi Vanvitelli, U.O.C. Clinica Pneumologica SUN, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy
Marialuisa Bocchino: Department of Clinical Medicine and Surgery, Section of Respiratory Disease, University Federico II, AORN dei Colli-Monaldi Hospital, 80138 Naples, Italy

IJERPH, 2020, vol. 17, issue 7, 1-7

Abstract: Alpha-1-antitrypsin deficiency (AATd) is a hereditary disease, mainly characterized by early onset and the lower lobes’ predominant emphysema. Bronchiectasis is characterized by dilatation of the bronchial wall and a clinical syndrome whose features are a cough, sputum production and frequent respiratory exacerbations. In the literature, there are many papers concerning these two clinical entities, but there is still a lot of debate about a possible association between them, in particular about the frequency of their association and causal links. The aim of this short communication is to show the literature reports about the association between AATd and bronchiectasis to establish the state of the art and possible future developments in this research field.

Keywords: alpha-1-antitrypsin deficiency; emphysema; bronchiectasis; respiratory infections (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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