Diet, Lifestyle and Cardiovascular Diseases: Linking Pathophysiology to Cardioprotective Effects of Natural Bioactive Compounds

Javad Sharifi-Rad, Célia F. Rodrigues, Farukh Sharopov, Anca Oana Docea, Aslı Can Karaca, Mehdi Sharifi-Rad, Derya Kahveci Karıncaoglu, Gözde Gülseren, Ezgi Şenol, Evren Demircan, Yasaman Taheri, Hafiz Ansar Rasul Suleria, Beraat Özçelik, Kadriye Nur Kasapoğlu, Mine Gültekin-Özgüven, Ceren Daşkaya-Dikmen, William C. Cho, Natália Martins and Daniela Calina
Additional contact information
Javad Sharifi-Rad: Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
Célia F. Rodrigues: LEPABE—Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
Farukh Sharopov: Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003 Dushanbe, Tajikistan
Anca Oana Docea: Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Aslı Can Karaca: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
Mehdi Sharifi-Rad: Department of Medical Parasitology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman 7616913555, Iran
Derya Kahveci Karıncaoglu: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
Gözde Gülseren: Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey
Ezgi Şenol: Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey
Evren Demircan: Department of Food Engineering, Chemical and Metallurgical Faculty, Istanbul Technical University, Maslak Istanbul 34469, Turkey
Yasaman Taheri: Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran
Hafiz Ansar Rasul Suleria: Department of Agriculture and Food Systems, The University of Melbourne, Melbourne 3010, Australia
Beraat Özçelik: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
Kadriye Nur Kasapoğlu: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
Mine Gültekin-Özgüven: Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Istanbul Technical University, Maslak, Istanbul 34469, Turkey
Ceren Daşkaya-Dikmen: Pladis TR R&D Department, Kısıklı mah., Ferah cad. Üsküdar İstanbul 34692, Turkey
William C. Cho: Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China
Natália Martins: Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal
Daniela Calina: Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania

IJERPH, 2020, vol. 17, issue 7, 1-31

Abstract: Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.

Keywords: food; diet; lifestyle; classical and emerging risk factors; atherosclerosis; arterial hypertension; diabetes; coronary artery disease; plant-food bioactive compounds; cardio-protective pharmacotherapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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