Epidemiological Characteristics and Spatiotemporal Trend Analysis of Human Brucellosis in China, 1950–2018

Huixin Yang, Siwen Zhang, Taijun Wang, Chenhao Zhao, Xiangyi Zhang, Jing Hu, Chenyu Han, Fangfang Hu, Jingjing Luo, Biao Li, Wei Zhao, Kewei Li, Ying Wang and Qing Zhen
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Huixin Yang: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Siwen Zhang: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Taijun Wang: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Chenhao Zhao: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Xiangyi Zhang: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Jing Hu: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Chenyu Han: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Fangfang Hu: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Jingjing Luo: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Biao Li: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China
Wei Zhao: Jilin Provincial Center for Disease Control and Prevention, Microbiological laboratory, Changchun 130000, China
Kewei Li: Jilin Provincial Center for Disease Control and Prevention, Microbiological laboratory, Changchun 130000, China
Ying Wang: Jilin Province First Institute of Endemic Disease Control, Brucellosis Research Laboratory, Changchun 130000, China
Qing Zhen: Jilin University School of Public Health, Department of Epidemiology and Biostatistics, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130000, China

IJERPH, 2020, vol. 17, issue 7, 1-15

Abstract: The rate of brucellosis, a zoonotic disease, has rapidly increased in humans brucellosis(HB) in recent years. In 1950–2018, a total of 684,380 HB cases (median 2274/year (interquartile range (IQR) 966–8325)) were reported to the National Infectious Disease Surveillance System in mainland China. The incidence of HB peaked in 2014 (4.32/100,000), and then showed a downward trend; we predict that it will maintain a steady downward trend in 2019–2020. Since 2015, the incidence of HB has shown opposite trends in the north and south of China; rates in the north have fallen and rates in the south have increased. In 2004–2018, the most significant increases in incidence of HB were in Yunnan (IQR 0.002–0.463/100,000), Hubei (IQR 0.000–0.338/100,000), and Guangdong (IQR 0.015–0.350/100,000). The areas where HB occurs have little overlap with areas with high per capita GDP in China. The “high–high” clusters of HB are located in northeastern China (Inner Mongolia, Heilongjiang, Jilin, Liaoning, Ningxia, Shanxi, and Gansu), and the “low–low” clusters of HB are located in southern China (Yunnan, Jiangxi, Shanghai, Guangxi, Guangdong, Zhejiang, Guizhou, and Hunan). In recent years, the incidence of HB in China has been controlled to some extent, but the incidence of HB has increased in southern China, and the disease has spread geographically in China from north to south. Further research is needed to address this change and to continue to explore the relationship between the incidence of HB and relevant factors.

Keywords: brucellosis; humans; epidemiology; zoonoses; China; GDP; spatiotemporal trend (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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