Increased Risk of Polycystic Ovary Syndrome and It’s Comorbidities in Women with Autoimmune Thyroid Disease

Chun-Wei Ho, Hsin-Hung Chen, Ming-Chia Hsieh, Ching-Chu Chen, Sheng-Pang Hsu, Hei-Tung Yip and Chia-Hung Kao
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Chun-Wei Ho: Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
Hsin-Hung Chen: Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
Ming-Chia Hsieh: Intelligent Diabetes Metabolism and Exercise Center, China Medical University Hospital, Taichung 40447, Taiwan
Ching-Chu Chen: Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
Sheng-Pang Hsu: Division of Endocrinology and Metabolism, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
Hei-Tung Yip: Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan
Chia-Hung Kao: Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 40447, Taiwan

IJERPH, 2020, vol. 17, issue 7, 1-8

Abstract: Objective: To investigate the prevalence of polycystic ovary syndrome (PCOS) and its comorbidities in patients with autoimmune thyroid disease (AITD). Population: In this cohort study, patients newly diagnosed as having Hashimoto thyroiditis (HT) or Grave disease (GD) were recruited into the AITD group. Method: The logistic regression model was used to investigate the association between exposure, endpoint, later diseases and treatment. Main Outcome Measures: We assessed the cumulative incidence using the Kaplan–Meier method and verified the difference by the log-rank test. Results: The AITD group included 3599 GD patients and 1332 HT patients. PCOS risk in patients with AITD was higher than that in the control group (adjusted hazard ratio = 1.39; 95% confidence interval = 1.07–1.71). In patients with both AITD and PCOS, the odds ratios of diabetes, hyperlipidemia and coronary artery disease were 2.48, 2.05 and 2.63, respectively. Conclusions: The risks of PCOS and its comorbidities such as diabetes, dyslipidemia and cardiac artery disease are high in patients with AITD in Taiwan.

Keywords: polycystic ovary syndrome (PCOS); autoimmune thyroid disease (AITD); hashimoto thyroiditis (HT); grave disease (GD) (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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