Impact of the Severities of Glaucoma on the Incidence of Subsequent Dementia: A Population-Based Cohort Study

Fu-Hsuan Kuo, Jui-Fu Chung, Min-Yen Hsu, Chia-Yi Lee, Jing-Yang Huang, Ming-Ju Hsieh and Shun-Fa Yang
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Fu-Hsuan Kuo: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Jui-Fu Chung: Radiology Division, Chiayi Branch, Taichung Veteran General Hospital, Chiayi 600, Taiwan
Min-Yen Hsu: Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Chia-Yi Lee: Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Jing-Yang Huang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Ming-Ju Hsieh: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

IJERPH, 2020, vol. 17, issue 7, 1-11

Abstract: The aim of the present study was to survey the relationship between the severity of glaucoma and subsequent dementia using the National Health Insurance Research Database (NHIRD) in Taiwan. Subjects with glaucoma were selected into the study group after an exclusion process, and each subject in the study group was propensity score-matched to another non-glaucoma patient that constituted the control group. The Cox proportional hazard regression that considered multiple potential risk factors of dementia was used to yield the adjusted hazard ratios (aHR) of dementia in different severities of glaucoma. There were 1185 (5.63 percent) subjects in the study group and 1119 (5.32 percent) patients in the control group that developed dementia. After adjusting for multiple confounders, there were no differences in the rate of any dementia (aHR: 0.961, 95% CI: 0.886–1.043, p = 0.3443), vascular dementia (aHR: 0.928, 95% CI: 0.846–1.018, p = 0.1154), Alzheimer’s disease (aHR: 1.018, 95% CI: 0.761–1.362, p = 0.9025) or Parkinson’s disease (aHR: 1.021, 95% CI: 0.886–1.176, p = 0.7744) between the study and the control groups. Regarding the disease severity of glaucoma, no difference was found in any type of dementia whether the glaucoma patients received less than two medical treatments, received more than two medical treatments, received drainage surgeries or received destructive surgeries. In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.

Keywords: glaucoma; dementia; epidemiology; severity; Alzheimer disease; Parkinson disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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