Welding Fumes, a Risk Factor for Lung Diseases

Maria Grazia Riccelli, Matteo Goldoni, Diana Poli, Paola Mozzoni, Delia Cavallo and Massimo Corradi
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Maria Grazia Riccelli: Department of Medicine and Surgery, University of Parma, via A. Gramsci 14, 43126 Parma, Italy
Matteo Goldoni: Department of Medicine and Surgery, University of Parma, via A. Gramsci 14, 43126 Parma, Italy
Diana Poli: INAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, via Fontana Candida 1, 00078 MontePorzio Catone (Rome), Italy
Paola Mozzoni: Department of Medicine and Surgery, University of Parma, via A. Gramsci 14, 43126 Parma, Italy
Delia Cavallo: INAIL Research, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, via Fontana Candida 1, 00078 MontePorzio Catone (Rome), Italy
Massimo Corradi: Department of Medicine and Surgery, University of Parma, via A. Gramsci 14, 43126 Parma, Italy

IJERPH, 2020, vol. 17, issue 7, 1-32

Abstract: (1) Background: Welding fumes (WFs) are composed of fine and ultrafine particles, which may reach the distal airways and represent a risk factor for respiratory diseases. (2) Methods: In vitro and in vivo studies to understand WFs pathogenesis were selected. Epidemiological studies, original articles, review, and meta-analysis to examine solely respiratory disease in welders were included. A systematic literature search, using PubMed, National Institute for Occupational Safety and Health Technical Information Center (NIOSHTIC), and Web of Science databases, was performed. (3) Results: Dose, time of exposure, and composition of WFs affect lung injury. Inflammation, lung defense suppression, oxidative stress, DNA damage, and genotoxic effects were observed after exposure both to mild and stainless steel WFs. (4) Conclusions: The detection of lung diseases associated with specific occupational exposure is crucial as complete avoidance or reduction of the exposure is difficult to achieve. Further studies in the area of particle research may aid the understanding of mechanisms involved in welding-related lung disease and to expand knowledge in welding-related cardiovascular diseases.

Keywords: welding fumes; particles; oxidative stress; inflammation; lung diseases (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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