Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Serena Bianchi, Stefania Annarita Nottola, Diana Torge, Maria Grazia Palmerini, Stefano Necozione and Guido Macchiarelli
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Serena Bianchi: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Stefania Annarita Nottola: Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, La Sapienza University of Rome, 00161 Rome, Italy
Diana Torge: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Maria Grazia Palmerini: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Stefano Necozione: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Guido Macchiarelli: Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy

IJERPH, 2020, vol. 17, issue 7, 1-15

Abstract: Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program’s Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant.

Keywords: mancozeb; female reproduction; fertility; systematic review (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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