The Relationship of IL-8 and IL-10 Myokines and Performance in Male Marathon Runners Presenting Exercise-Induced Bronchoconstriction

Juliana de Melo Batista dos Santos, André Luis Lacerda Bachi, Luiz Antonio Luna Junior, Roberta Foster, Ana Paula Renno Sierra, Marino Benetti, José Roberto Araújo, Nabil Ghorayeb, Maria Augusta Peduti Dal’Molim Kiss, Rodolfo P. Vieira, Dominique M. A. Bullens and Mauro Vaisberg
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Juliana de Melo Batista dos Santos: Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil
André Luis Lacerda Bachi: Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil
Luiz Antonio Luna Junior: Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil
Roberta Foster: Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil
Ana Paula Renno Sierra: School of Physical Education and Sport, University of São Paulo (USP), São Paulo 05508-030, Brazil
Marino Benetti: School of Physical Education and Sport, University of São Paulo (USP), São Paulo 05508-030, Brazil
José Roberto Araújo: Department of Morphology and Genetics, Federal University of Sao Paulo (UNIFESP), São Paulo 04023-900, Brazil
Nabil Ghorayeb: Sports Cardiology Department, Dante Pazzanese Institute of Cardiology, São Paulo 04012-909, Brazil
Maria Augusta Peduti Dal’Molim Kiss: School of Physical Education and Sport, University of São Paulo (USP), São Paulo 05508-030, Brazil
Rodolfo P. Vieira: Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos 11060-001, Brazil
Dominique M. A. Bullens: Clinical Division of Pediatrics, UZ Leuven, 3000 Leuven, Belgium
Mauro Vaisberg: Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04025-002, Brazil

IJERPH, 2020, vol. 17, issue 8, 1-15

Abstract: At present, it is unclear which exercise-induced factors, such as myokines, could diminish the negative impact of the reduction in pulmonary function imposed by the exercise in question. In this study, we aim to evaluate the prevalence of exercise-induced bronchoconstriction (EIB) and also to investigate the effect of myokines in the performance of marathon runners presenting EIB or not. Thirty-eight male recreational marathon runners (age 38.8 [33–44], height 175.7 [172.0–180.3]; weight 74.7 [69.3–81.6]) participated in this study, and through spirometry tests, a prevalence of 23.6% of EIB was found, which is in agreement with the literature. The volunteers who tested positive to EIB (EIB+) presented lower maximum aerobic capacity compared to those who tested negative (EIB−) (EIB+ 44.02 [39.56–47.02] and EIB− 47.62 [44.11–51.18] p = 0.03). The comparison of plasma levels of IL-1β (EIB+ p = 0.296, EIB− p = 0.176, EIB+ vs. EIB− baseline p = 0.190 immediately after p = 0.106), IL-4 (undetectable), IL-6 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.301 immediately after p = 0.614), IL-8 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.110 immediately after p = 0.453), IL-10 (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.424 immediately after p = 0.876) and TNF-α (EIB+ p = 0.003, EIB− p ≤ 0.001, EIB+ vs. EIB− baseline p = 0.141 immediately after p = 0.898) were similar in both groups 24 h before and immediately after the marathon. However, negative correlations were found between the marathon finishing time and the levels of IL-8 (r = −0.81, p = 0.022), and IL-10 (r = −0.97, p ≤ 0.001) immediately after completing the marathon. In conclusion, for the first time, it is shown that the myokines IL-8 and IL-10 are related to improvement of the performance of marathon runners presenting EIB.

Keywords: pulmonary function; endurance exercise; EIB; cytokines; FEV1; FVC; aerobic capacity (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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