The Effect of Vitamin D 3 Supplementation on Hepcidin, Iron, and IL-6 Responses after a 100 km Ultra-Marathon

Katarzyna Kasprowicz, Wojciech Ratkowski, Wojciech Wołyniec, Mariusz Kaczmarczyk, Konrad Witek, Piotr Żmijewski, Marcin Renke, Zbigniew Jastrzębski, Thomas Rosemann, Pantelis T. Nikolaidis and Beat Knechtle
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Katarzyna Kasprowicz: Department of Molecular Biology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Wojciech Ratkowski: Department of Athletics, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Wojciech Wołyniec: Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, Poland
Mariusz Kaczmarczyk: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, 70-11 Szczecin, Poland
Konrad Witek: Department of Biochemistry, Institute of Sport, National Research Institute, 01-982 Warsaw, Poland
Piotr Żmijewski: Faculty of Physical Education, Jozef Piłsudski University of Physical Education in Warsaw, 01-813 Warsaw, Poland
Marcin Renke: Department of Occupational, Metabolic and Internal Diseases, Medical University of Gdansk, 81-519 Gdynia, Poland
Zbigniew Jastrzębski: Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Thomas Rosemann: Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland
Pantelis T. Nikolaidis: Exercise Physiology Laboratory, 18450 Nikaia, Greece
Beat Knechtle: Institute of Primary Care, University of Zurich, 8091 Zurich, Switzerland

IJERPH, 2020, vol. 17, issue 8, 1-13

Abstract: Deficiencies in iron and vitamin D are frequently observed in athletes. Therefore, we examined whether different baseline vitamin D 3 levels have any impact on post-exercise serum hepcidin, IL-6 and iron responses in ultra-marathon runners. In this randomized control trial, the subjects (20 male, amateur runners, mean age 40.75 ± 7.15 years) were divided into two groups: experimental (VD) and control (CON). The VD group received vitamin D 3 (10,000 UI/day) and the CON group received a placebo for two weeks before the run. Venous blood samples were collected on three occasions—before the run, after the 100 km ultra-marathon and 12 h after the run—to measure iron metabolism indicators, hepcidin, and IL-6 concentration. After two weeks of supplementation, the intervention group demonstrated a higher level of serum 25(OH)D than the CON group (27.82 ± 5.8 ng/mL vs. 20.41 ± 4.67 ng/mL; p < 0.05). There were no differences between the groups before and after the run in the circulating hepcidin and IL-6 levels. The decrease in iron concentration immediately after the 100-km ultra-marathon was smaller in the VD group than CON ( p < 0.05). These data show that various vitamin D 3 status can affect the post-exercise metabolism of serum iron.

Keywords: ultra-endurance; metabolism; nutrition; iron deficiency (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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