Promising Scaffold-Free Approaches in Translational Dentistry

Marco Tatullo, Benedetta Marrelli, Francesca Palmieri, Massimiliano Amantea, Manuel Nuzzolese, Rosa Valletta, Barbara Zavan and Danila De Vito
Additional contact information
Marco Tatullo: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70122 Bari, Italy
Benedetta Marrelli: Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy
Francesca Palmieri: Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy
Massimiliano Amantea: Marrelli Health, Tecnologica Research Institute, 88900 Crotone, Italy
Manuel Nuzzolese: North Manchester General Hospital, Manchester M8 5RB, UK
Rosa Valletta: Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples, 80131 Naples, Italy
Barbara Zavan: Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
Danila De Vito: Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70122 Bari, Italy

IJERPH, 2020, vol. 17, issue 9, 1-8

Abstract: Regenerative medicine has recently improved the principal therapies in several medical fields. In the past ten years, the continuous search for novel approaches to treat the most common dental pathologies has developed a new branch called regenerative dentistry. The main research fields of translational dentistry involve biomimetic materials, orally derived stem cells, and tissue engineering to populate scaffolds with autologous stem cells and bioactive growth factors. The scientific literature has reported two main research trends in regenerative dentistry: scaffold-based and scaffold-free approaches. This article aims to critically review the main biological properties of scaffold-free regenerative procedures in dentistry. The most impactful pros and cons of the exosomes, the leading role of hypoxia-based mesenchymal stem cells (MSCs), and the strategic use of heat shock proteins in regenerative dentistry will be highlighted and discussed in terms of the use of such tools in dental regeneration and repair.

Keywords: scaffolds; dental materials; regenerative dentistry; dentistry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/9/3001/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/9/3001/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:9:p:3001-:d:350572

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().