The Length and Number of Sedentary Bouts Predict Fibrinogen Levels in Postmenopausal Women

Pascal Izzicupo, Andrea Di Blasio, Andrea Di Credico, Giulia Gaggi, Anastasios Vamvakis, Giorgio Napolitano, Fabrizio Ricci, Sabina Gallina, Barbara Ghinassi and Angela Di Baldassarre
Additional contact information
Pascal Izzicupo: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Andrea Di Blasio: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Andrea Di Credico: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Giulia Gaggi: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Anastasios Vamvakis: 3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Giorgio Napolitano: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Fabrizio Ricci: Department of Neuroscience, Imaging and Clinical Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Sabina Gallina: Department of Neuroscience, Imaging and Clinical Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Barbara Ghinassi: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy
Angela Di Baldassarre: Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti and Pescara, Italy

IJERPH, 2020, vol. 17, issue 9, 1-12

Abstract: Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p < 0.01), lying down during awake time (r = −0.50, p < 0.01), and both medium (11–30 mins) and very long bouts (>1 h) of SB (r = −0.59, p < 0.01; r = −0.51, p < 0.01, respectively), and inversely correlated with moderate to vigorous-intensity physical activity (r = −0.39, p < 0.01). Furthermore, fibrinogen was also directly correlated with BMI (r = −0.28, p < 0.05). In postmenopausal women without prevalent cardiovascular disease, the number of prolonged and uninterrupted sedentary bouts is directly correlated with increased fibrinogen levels, regardless of PA and BMI. This result suggests the importance of delivering new strategies to counteract the increase of sedentariness and inactivity of the postmenopausal population.

Keywords: hemostasis; cardiovascular disease risk; sedentary behavior; physical activity; women’s health; menopause (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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