Changes of Somatosensory Phenotype in the Course of Disease in Osteoarthritis Patients

Johanna Höper, Lara Schraml, Janne Gierthmühlen, Stephanie M. Helfert, Stefanie Rehm, Susanne Härtig, Ove Schröder, Michael Lankes, Frieder C. Traulsen, Andreas Seekamp and Ralf Baron
Additional contact information
Johanna Höper: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Lara Schraml: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Janne Gierthmühlen: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Stephanie M. Helfert: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Stefanie Rehm: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Susanne Härtig: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Ove Schröder: Department of Orthopedics and Trauma Surgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Michael Lankes: Private Practice for Orthopedics and Trauma Surgery am Arndtplatz, 24116 Kiel, Germany
Frieder C. Traulsen: Private Practice for Orthopedics and Trauma Surgery am Arndtplatz, 24116 Kiel, Germany
Andreas Seekamp: Department of Orthopedics and Trauma Surgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
Ralf Baron: Department of Neurology, Division of Neurological Pain Research and Therapy, Universitätsklinikum Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany

IJERPH, 2020, vol. 17, issue 9, 1-11

Abstract: To investigate sensory changes, physical function (pF), quality of life (QoL) and pain intensity of patients with osteoarthritis (OA) in the natural course of disease, and patients undergoing total joint replacement therapy (TJR) 31 (20 females, mean age 64.6 ± 10.4 years), patients with OA were investigated with questionnaires and quantitative sensory testing (QST) in the area of referred pain at the thigh at baseline and follow-up 22–49 weeks later; changes were analyzed separately for patients with ( n = 13) and without TJR ( n = 18). In patients without TJR pain intensity, pF, QoL did not improve, and increased pain sensitivity to cold and a stronger loss of detection were observed. In patients after TJR, however, a reduction in mechanical pain sensitivity and allodynia occurred in accordance with a reduction of pain intensity and improvement of functionality while QoL did not improve. Additionally, an increased sensitivity to heat pain and a more pronounced loss of mechanical detection could be observed in this group. TJR seems to stop peripheral pain input leading to a reduction of pain intensity and central sensitization, but surgery-induced sensory changes such as peripheral sensitization and loss of detection occur. Furthermore, TJR has favorable effects on pain intensity and functionality but not QoL.

Keywords: osteoarthritis; quantitative sensory testing; total joint replacement; somatosensory phenotype; sensitization (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/17/9/3085/pdf (application/pdf)
https://www.mdpi.com/1660-4601/17/9/3085/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:17:y:2020:i:9:p:3085-:d:351766

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().