Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis

Pamela Di Giovanni, Giuseppe Di Martino, Piera Scampoli, Fabrizio Cedrone, Francesca Meo, Giuseppe Lucisano, Ferdinando Romano and Tommaso Staniscia
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Pamela Di Giovanni: Department of Pharmacy, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Giuseppe Di Martino: Department of Medicine and Aging Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Piera Scampoli: School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Fabrizio Cedrone: School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Francesca Meo: School of Hygiene and Preventive Medicine, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Giuseppe Lucisano: Centre for Outcomes Research and Clinical Epidemiology (CORESEARCH), Via Tiziano Veciello, 65100 Pescara, Italy
Ferdinando Romano: Department of Public Health and Infectious Diseases, “La Sapienza” University of Rome, P.zza Aldo Moro 5, 00100 Rome, Italy
Tommaso Staniscia: Department of Medicine and Aging Sciences, “G. d’Annunzio” University Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy

IJERPH, 2020, vol. 17, issue 9, 1-11

Abstract: Background : Arsenic is a toxic metalloid element widely distributed throughout the environment. Arsenic contaminated water has become an ongoing public health issue affecting hundred million people worldwide. The aim of this paper was to summarize the evidence in the association between arsenic metabolites and urinary tract cancer risk. Methods : A systematic review was conducted searching for observational studies that evaluated the association of arsenic metabolites and urinary tract cancer. Risk estimates from individual studies were pooled by using random effects models. Results : All the metabolites considered in this study resulted to be significantly associated to urothelial cancer, respectively: IA% 3.51 (1.21–5.82) ( p = 0.003), MMA with WMD = 2.77 (1.67–3.87) ( p < 0.001) and DMA with WMD = −4.56 (−7.91–1.22) ( p = 0.008). Conclusions : Arsenic metabolites are significantly associated to urothelial cancer. Future studies will help to verify the independent association(s) between arsenic metabolites and urothelial cancer.

Keywords: arsenic; urothelial cancer; meta-analysis; drinking water (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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