Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Mengying Wang, Siyue Wang, Xiaowen Wang, Junhui Wu, Yao Wu, Zijing Wang, Jiating Wang, Tao Wu and Yonghua Hu
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Mengying Wang: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Siyue Wang: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Xiaowen Wang: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Junhui Wu: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Yao Wu: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Zijing Wang: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Jiating Wang: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Tao Wu: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Yonghua Hu: Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China

IJERPH, 2020, vol. 18, issue 1, 1-11

Abstract: Background: Carotid intima-media thickness (cIMT) has been associated with an elevated risk of ischemic stroke (IS) in several studies, but the results are inconsistent. We investigated whether the association between cIMT and IS varied across different IS subtypes, and further assessed gene–cIMT interactions’ association with IS risk. Methods: A total of 1048 IS cases (795 large-artery atherosclerosis (LAA) cases, 103 small-vessel occlusion (SVO) cases, and 150 other subtypes) and 2696 IS-free controls across 2179 families were included in the analysis. Self-reported IS cases were confirmed through medical records’ review and head imaging by computed tomography and/or magnetic resonance imaging. The mean values of the common cIMT obtained in bilateral distal and proximal carotid artery segments were used. The genotype information of rs2910164 polymorphism in microRNA-146a (miR-146a) was also collected. Results: We found that cIMT was significantly associated with a higher risk of IS and LAA subtype but not SVO subtype in the multivariate-adjusted models. The odds ratio (OR) and 95% confidence interval (CI) in the highest quartile versus the lowest quartile of cIMT was 2.48 (1.92–3.20) for IS and 2.75 (2.08–3.64) for LAA (both p trend <0.001). The results also showed that there was a significant interaction between cIMT and rs2910164 genotype with the risk of IS ( p interaction = 0.03) and LAA ( p interaction = 0.02). The associations of cIMT with IS and LAA were strengthened among participants carried rs2910164_GG genotype compared with those with rs2910164_CC genotype. Conclusions: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a.

Keywords: carotid intima-media thickness; genetic risk; ischemic stroke (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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