Incidence of Thyroid Cancer in Italian Contaminated Sites

Marta Benedetti, Amerigo Zona, Paolo Contiero, Eleonora D’Armiento, Ivano Iavarone and Working Group Airtum
Additional contact information
Marta Benedetti: Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy
Amerigo Zona: Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy
Paolo Contiero: Environmental Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Eleonora D’Armiento: Internal Medicine Unit, Department of Medico-Surgical Sciences and Biotechnologies, ICOT Hospital, University of Rome, 04100 Latina, Italy
Ivano Iavarone: Department of Environment and Health, Istituto Superiore di Sanità, 00161 Rome, Italy
Working Group Airtum: AIRTUM Working Group (AIRTUM Working Group members are listed in Appendix A).

IJERPH, 2020, vol. 18, issue 1, 1-16

Abstract: Some human literature suggests a possible role of endocrine disruptors (EDs) exposure in thyroid cancer (TC) development. We investigated TC incidence in selected Italian National Priority Contaminated Sites (NPCS) with documented presence of EDs considered thyroid carcinogens. Adjusted Standardized Incidence Ratios (SIRs), with their 90% confidence intervals, were computed by gender, and age-specific groups (aged 15–39 years, and 40 years or over) for each NPCS in the period 2006 to 2013. In the age group of 15–39 years, a significant excess of TC risk was found in two NPCSs in males; non-significant excess risks were observed in four NPCSs in males, and in five in females. In the age group of 40 years and over, significant excess risks were found in six NPCSs in males and in seven NPCSs in females; non-significant excess risks were identified in two NPCSs in males and females. The findings of several excesses in incidence, mainly observed in adults aged 40 years or over, are suggestive of a possible adverse effect associated with residence in NPCSs, even if a role of other factors cannot be excluded, due to the adoption of an ecological study design. Future analytical studies are needed to clarify if EDs are a TC risk factor for individuals living in NPCSs.

Keywords: thyroid cancer; incidence; endocrine disruptors; environmental exposure (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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