Gender Differences and Quality of Life in Parkinson’s Disease

Pietro Crispino, Miriam Gino, Elena Barbagelata, Tiziana Ciarambino, Cecilia Politi, Immacolata Ambrosino, Rosalia Ragusa, Marina Marranzano, Antonio Biondi and Marco Vacante
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Pietro Crispino: Internal Medicine Department, Lagonegro Hospital, 85042 Lagonegro (PZ), Italy
Miriam Gino: Department of Internal Medicine, Rivoli Hospital, 10098 Rivoli (TO), Italy
Elena Barbagelata: Department of Internal Medicine, ASL 4 Chiavarese, Sestri Levante Hospital, 16039 Sestri Levante (GE), Italy
Tiziana Ciarambino: Department of Medical, Surgical, Neurological, Metabolic and Geriatrics Sciences, Marcianise Hospital, ASL Caserta, University of Campania “L. Vanvitelli”, 81025 Naples, Italy
Cecilia Politi: Department of Internal Medicine, Veneziale Hospital, 86170 Isernia, Italy
Immacolata Ambrosino: ASL Bari, 70023 Bari, Italy
Rosalia Ragusa: Health Technology Assessment Committee, University Hospital G. Rodolico, 95123 Catania, Italy
Marina Marranzano: Department of Medical, Surgical and Advanced Sciences, University of Catania, 95123 Catania, Italy
Antonio Biondi: Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy
Marco Vacante: Department of General Surgery and Medical-Surgical Specialties, University of Catania, 95123 Catania, Italy

IJERPH, 2020, vol. 18, issue 1, 1-13

Abstract: Parkinson’s disease has been found to significantly affect health-related quality of life. The gender differences of the health-related quality of life of subjects with Parkinson’s disease have been observed in a number of studies. These differences have been reported in terms of the age at onset, clinical manifestations, and response to therapy. In general, women with Parkinson’s disease showed more positive disease outcomes with regard to emotion processing, non-motor symptoms, and cognitive functions, although women report more Parkinson’s disease-related clinical manifestations. Female gender predicted poor physical functioning and socioemotional health-related quality of life, while male gender predicted the cognitive domain of health-related quality of life. Some studies reported gender differences in the association between health-related quality of life and non-motor symptoms. Depression and fatigue were the main causes of poorer health-related quality of life in women, even in the early stages of Parkinson’s disease. The aim of this review was to collect the best available evidence on gender differences in the development of Parkinson’s disease symptoms and health-related quality of life.

Keywords: Parkinson’s disease; gender; dopamine; levodopa; quality of life (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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