Effect of Periodontitis and Scaling and Root Planing on Risk of Pharyngeal Cancer: A Nested Case—Control Study

Ping-Ju Chen, Yin-Yang Chen, Chiao-Wen Lin, Ying-Tung Yeh, Han-Wei Yeh, Jing-Yang Huang, Shun-Fa Yang and Chao-Bin Yeh
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Ping-Ju Chen: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Yin-Yang Chen: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chiao-Wen Lin: Institute of Oral Sciences, Chung Shan Medical University, Taichung 402, Taiwan
Ying-Tung Yeh: Department of Dentistry, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Han-Wei Yeh: School of Medicine, Chang Gung University, Taoyuan City 333, Taiwan
Jing-Yang Huang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chao-Bin Yeh: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan

IJERPH, 2020, vol. 18, issue 1, 1-12

Abstract: This study investigated the association between periodontitis and the risk of pharyngeal cancer in Taiwan. For this population-based nested case–control study using the Longitudinal Health Insurance Database derived from Taiwan’s National Health Insurance Research Database, we identified patients ( n = 1292) who were newly diagnosed with pharyngeal cancer between 2005 and 2013 and exactly paired them with propensity score matched control subjects ( n = 2584). Periodontitis and scaling and root planing (SRP) were identified before the index date. Pharyngeal cancer was subdivided into 3 subgroups on the basis of anatomic location: nasopharyngeal cancer, oropharyngeal cancer, and hypopharyngeal cancer. A multiple conditional logistic regression model was applied to analyze the adjusted odds ratio (aOR). Periodontitis was associated with an increased risk of pharyngeal cancer (aOR, 1.57; 95% confidence interval (CI), 1.17 to 2.10), especially oropharyngeal cancer (aOR, 2.22; 95% CI, 1.07 to 4.60). We found a decreased risk of pharyngeal cancer in patients who had undergone SRP (aOR, 0.77; 95% CI, 0.61 to 0.96). In conclusion, this study showed that periodontitis was associated with an increased risk of pharyngeal cancer and SRP exerted a protective effect against pharyngeal cancer. Our results suggest that treating periodontitis and performing SRP, which are modifiable factors in oral health, in clinical practice may provide an opportunity to decrease the disease burden of pharyngeal cancer in Taiwan.

Keywords: periodontitis; pharynx cancer; scaling; root planing (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2020
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