Effects of Soy Isoflavones on Biochemical Markers of Bone Metabolism in Postmenopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Wiesław Kanadys, Agnieszka Barańska, Agata Błaszczuk, Małgorzata Polz-Dacewicz, Bartłomiej Drop, Maria Malm and Krzysztof Kanecki
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Wiesław Kanadys: Specialistic Medical Center “Czechów” in Lublin, 20-848 Lublin, Poland
Agnieszka Barańska: Department of Medical Informatics and Statistics with E-learning Lab, Medical University of Lublin, 20-090 Lublin, Poland
Agata Błaszczuk: Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland
Małgorzata Polz-Dacewicz: Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland
Bartłomiej Drop: Department of Medical Informatics and Statistics with E-learning Lab, Medical University of Lublin, 20-090 Lublin, Poland
Maria Malm: Department of Medical Informatics and Statistics with E-learning Lab, Medical University of Lublin, 20-090 Lublin, Poland
Krzysztof Kanecki: Department of Social Medicine and Public Health, Warsaw Medical University, 02-007 Warsaw, Poland

IJERPH, 2021, vol. 18, issue 10, 1-22

Abstract: This systematic review and meta-analysis of randomized controlled trials was performed to more completely assess potential changes in bone turnover marker levels in postmenopausal women during the intake of soy isoflavones. PubMed (Medline) and EMBASE were searched for relevant studies, and their quality was evaluated according to Cochrane criteria. The levels of markers were evaluated in a total of 1114 women who ingested mean daily doses of 98.2 mg (30.9 to 300) of soy isoflavones for 3 to 24 months, in comparison to those of 1081 subjects who used a placebo. Ten, eighteen, eight, and fourteen comparison studies were finally selected for an estimation of the effects on osteocalcin (OC), bone alkaline phosphatase (BAP), pyridinoline (PYD), and deoxypyridinoline (DPD), respectively. A summary of the results of intervention was as follows: 4.16%, 95% CI: –7.72–16.04, p = 0.49 for OC; 5.50%, 95% CI: –3.81–14.82, p = 0.25 for BAP; –12.09%, 95% CI: –25.37–1.20, p = 0.07 for PYD; and –7.48%, 95% CI: –15.37–0.41, p = 0.06 for DPD. The meta-analysis of the included studies revealed some statistically insignificant observations that soy isoflavones intake is associated with a trend in increased levels of OC and BAP, as well as a trend in reduced levels of PYD and DPD. Soy isoflavones may have a beneficial effect on bone formation markers, but this requires extensive multi-center research.

Keywords: soy isoflavones; natural products; bone turnover markers; postmenopausal women; bone mineral density (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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