Analysis of Effectiveness of a Supplement Combining Harpagophytum procumbens, Zingiber officinale and Bixa orellana in Healthy Recreational Runners with Self-Reported Knee Pain: A Pilot, Randomized, Triple-Blind, Placebo-Controlled Trial

Marcela González-Gross, Carlos Quesada-González, Javier Rueda, Manuel Sillero-Quintana, Nicolas Issaly, Angel Enrique Díaz, Eva Gesteiro, David Escobar-Toledo, Rafael Torres-Peralta, Marc Roller and Amelia Guadalupe-Grau
Additional contact information
Marcela González-Gross: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Carlos Quesada-González: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Javier Rueda: Biomechanical Laboratory, Faculty of Physical Activity and Sport Sciences, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Manuel Sillero-Quintana: Department of Sport, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Nicolas Issaly: Natural Origins, 69380 Lozanne, France
Angel Enrique Díaz: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Eva Gesteiro: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
David Escobar-Toledo: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Rafael Torres-Peralta: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain
Marc Roller: Natural Origins, 69380 Lozanne, France
Amelia Guadalupe-Grau: ImFINE Research Group, Department of Health and Human Performance, Universidad Politécnica de Madrid, 28040 Madrid, Spain

IJERPH, 2021, vol. 18, issue 11, 1-18

Abstract: Recreational running (RR) is becoming a popular way to increase physical activity for improving health, together with a higher incidence of knee injuries. The aim was to analyze the effect of a four-week supplementation with a mixture of Harpagophytum procumbens , Zingiber officinale and Bixa orellana on males, middle-aged, RR with an undiagnosed knee discomfort. A randomized triple-blind placebo-control trial was conducted among male RR aged 40–60 years suffering from self-declared knee discomfort after training. Participants were assigned to supplementation (2 g/day in 6 doses; n ? = ?13; intervention group (IG)) or matched placebo ( n ? = ?15; control group (CG)) for 4?weeks. At pre- and post-intervention, assessment of routine blood biomarkers, body composition, running biomechanics and body temperature was performed using standardized procedures. Machine learning (ML) techniques were used to classify whether subjects belonged to IG or CG. ML model was able to correctly classify individuals as IG or CG with a median accuracy of 0.857. Leg fat mass decreased significantly ( p = 0.037) and a deeper reduction in knee thermograms was observed in IG ( p < 0.05). Safety evaluation revealed no significant differences in the rest of parameters studied. Subjects belonging to IG or CG are clearly differentiated, pointing into an effect of the supplement of ameliorating inflammation.

Keywords: knee joint inflammation; recreational runners; biomechanical phenomena; thermography; Harpagophytum procumbens; Zingiber officinale; Bixa orellana (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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