Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies

Xianglian Yu, Yijun Ruan, Yawen Zhang, Jiayi Wang, Yuting Liu, Jibiao Zhang and Lin Zhang
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Xianglian Yu: Department of Education, Jianghan University, Wuhan 430056, China
Yijun Ruan: Department of Psychology, The Chinese University of Hong Kong, Hong Kong 999077, China
Yawen Zhang: Department of Medical Psychology, School of Health Humanities, Peking University, Beijing 100191, China
Jiayi Wang: Department of Education, Jianghan University, Wuhan 430056, China
Yuting Liu: Department of Education, Jianghan University, Wuhan 430056, China
Jibiao Zhang: Department of Education, Jianghan University, Wuhan 430056, China
Lin Zhang: Key Laboratory of Adolescent Cyberpsychology and Behavior, Ministry of Education, Key Laboratory of Human Development and Mental Health of Hubei Province, School of Psychology, Central China Normal University, Wuhan 430056, China

IJERPH, 2021, vol. 18, issue 11, 1-11

Abstract: Objective: The present meta-analysis aimed to explore the cognitive and neural mechanism of social anxiety disorder (SAD) from a whole-brain view, and compare the differences in brain activations under different task paradigms. Methods: We searched Web of Science Core Collection and other databases with the keywords related to social anxiety, social phobia, and functional magnetic resonance imaging (fMRI) for comparing persons with SAD to healthy controls and used the activation likelihood estimation method. Thirty-seven papers met the inclusion criteria, including 15 with emotional faces as stimuli, 8 presenting specific situations as stimuli, and 14 using other types of tasks as stimuli. Among these papers, 654 participants were in the SAD group and 594 participants were in the control group with 335 activation increase points and 115 activation decrease points. Results: Whole-brain analysis showed that compared with healthy controls, persons with SAD showed significantly lower activation of the left anterior cingulate gyrus (MNI coordinate: x = ?6, y = 22, z = 38; p 0.001). Sub-group analysis based on task indicated that when performing tasks with emotional faces as stimuli, persons with SAD showed significantly lower activation of the left cerebellar slope and fusiform gyrus (MNI coordinate: x = ?26, y = ?68, z = ?12; p 0.001), and significantly higher activation of the right supramarginal gyrus and angular gyrus, than healthy controls (MNI coordinate: x = 58, y = ?52, z = 30; p 0.001). Conclusion: Individuals with social anxiety disorder show abnormal activation in the cingulate gyrus, which is responsible for the process of attention control, and task type can influence the activation pattern.

Keywords: social anxiety disorder; fMRI study; meta-analysis; activity likelihood estimation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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