Evaluation of a Post-Operative Rehabilitation Program in Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Pilot Study

Sveva Maria Nusca, Attilio Parisi, Paolo Mercantini, Marcello Gasparrini, Francesco Antonio Pitasi, Alessandra Lacopo, Vincenzo Colonna, Giulia Stella, Claudia Cerulli, Elisa Grazioli, Eliana Tranchita, Flavia Santoboni, Eleonora Latini, Donatella Trischitta, Mario Vetrano, Vincenzo Visco, Antonio Pavan and Maria Chiara Vulpiani
Additional contact information
Sveva Maria Nusca: PhD Course in “Translational Medicine and Oncology”, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Attilio Parisi: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Paolo Mercantini: Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Marcello Gasparrini: Department of General Surgery, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Francesco Antonio Pitasi: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Alessandra Lacopo: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Vincenzo Colonna: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Giulia Stella: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Claudia Cerulli: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Elisa Grazioli: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Eliana Tranchita: Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, 00135 Rome, Italy
Flavia Santoboni: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Eleonora Latini: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Donatella Trischitta: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Mario Vetrano: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Vincenzo Visco: Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Antonio Pavan: Department of Clinical and Molecular Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy
Maria Chiara Vulpiani: Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences and Translational Medicine, Sant’Andrea University Hospital, “Sapienza” University of Rome, 00189 Rome, Italy

IJERPH, 2021, vol. 18, issue 11, 1-19

Abstract: This pilot study explores the effects of a post-operative physical exercise program on the quality of life (QoL) and functional and nutritional parameters of patients that underwent laparoscopic colorectal cancer surgery, compared to usual care alone. The intervention group (IG) attended a 2-month-long supervised and combined exercise–training program during the post-operative period. Both IG and control group (CG) participated in the QoL, functional, and nutritional assessments before exercise training (T0), 2 months after the beginning of the exercise (end of treatment) (T1), and 2 (T2) and 4 (T3) months from the end of treatment. Eleven patients with colorectal cancer that underwent laparoscopic surgery were enrolled (six intervention; five control). The IG showed significant improvements compared to the CG in “Physical functioning” (PF2) ( p = 0.030), “Cognitive functioning” (CF) ( p = 0.018), and “Fatigue” (FA) ( p = 0.017) of the European Organization for Research and Treatment of Cancer Quality of Life-C30 Questionnaire (EORTC QLQ-C30) at T1; in SMWT ( p = 0.022) at T1; in PF2 ( p = 0.018) and FA ( p = 0.045) of EORTC QLQ-C30 at T2, in phase angle (PhA) of bioelectrical impedance analysis ( p = 0.022) at T3. This pilot study shows that a post-operative, combined, and supervised physical exercise program may have positive effects in improving the QoL, functional capacity, and nutritional status in patients that undergo laparoscopic colorectal cancer surgery.

Keywords: oncology; physical exercise; combined exercise; supervised exercise; Enhanced Recovery after Surgery (ERAS); quality of life (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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