Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy

Won-Kyu Jang, Su-Yeon Lee, Sunggyun Park, Nam Hee Ryoo, Ilseon Hwang, Ji Min Park and Jin-Gon Bae
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Won-Kyu Jang: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Su-Yeon Lee: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Sunggyun Park: Departments of Laboratory Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Nam Hee Ryoo: Departments of Laboratory Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Ilseon Hwang: Department of Pathology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Ji Min Park: Department of Pathology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
Jin-Gon Bae: Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea

IJERPH, 2021, vol. 18, issue 11, 1-7

Abstract: There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.

Keywords: COVID-19; SARS-CoV-2; vertical infection transmission; COVID-19 antibody; neutralizing antibody; first trimester pregnancy; placenta; pathology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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