Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort

Marion Ouidir, Emie Seyve, Emmanuel Rivière, Julien Bernard, Marie Cheminat, Jérôme Cortinovis, François Ducroz, Fabrice Dugay, Agnès Hulin, Itai Kloog, Anne Laborie, Ludivine Launay, Laure Malherbe, Pierre-Yves Robic, Joel Schwartz, Valérie Siroux, Jonathan Virga, Cécile Zaros, Marie-Aline Charles, Rémy Slama and Johanna Lepeule
Additional contact information
Marion Ouidir: Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France
Emie Seyve: Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France
Emmanuel Rivière: ASPA, ATMO Grand Est, 67300 Schiltigheim, France
Julien Bernard: ASPA, ATMO Grand Est, 67300 Schiltigheim, France
Marie Cheminat: Ined-Inserm-EFS Joint Unit ELFE, 75020 Paris, France
Jérôme Cortinovis: ATMO Normandie, 76000 Rouen, France
François Ducroz: AIR Pays-de-la-Loire, 44300 Nantes, France
Fabrice Dugay: AIRPARIF, 75004 Paris, France
Agnès Hulin: ATMO Nouvelle-Aquitaine, 33000 Bordeaux, France
Itai Kloog: Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva P.O. Box 653, Israel
Anne Laborie: ATMO France, 75004 Paris, France
Ludivine Launay: U1086 INSERM-UCN ‘Anticipe’, 14000 Caen, France
Laure Malherbe: National Institute for Industrial Environment and Risks (INERIS), 60550 Verneuil en Halatte, France
Pierre-Yves Robic: ATMO Occitanie, 31330 Toulouse, France
Joel Schwartz: Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA
Valérie Siroux: Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France
Jonathan Virga: ATMO PACA, 13006 Marseille, France
Cécile Zaros: Ined-Inserm-EFS Joint Unit ELFE, 75020 Paris, France
Marie-Aline Charles: Ined-Inserm-EFS Joint Unit ELFE, 75020 Paris, France
Rémy Slama: Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France
Johanna Lepeule: Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France

IJERPH, 2021, vol. 18, issue 11, 1-17

Abstract: Background: Studies have reported associations between maternal exposure to atmospheric pollution and lower birth weight. However, the evidence is not consistent and uncertainties remain. We used advanced statistical approaches to robustly estimate the association of atmospheric pollutant exposure during specific pregnancy time windows with term birth weight (TBW) in a nationwide study. Methods: Among 13,334 women from the French Longitudinal Study of Children (ELFE) cohort, exposures to PM 2.5 , PM 10 (particles < 2.5 µm and <10 µm) and NO 2 (nitrogen dioxide) were estimated using a fine spatio-temporal exposure model. We used inverse probability scores and doubly robust methods in generalized additive models accounting for spatial autocorrelation to study the association of such exposures with TBW. Results: First trimester exposures were associated with an increased TBW. Second trimester exposures were associated with a decreased TBW by 17.1 g (95% CI, ?26.8, ?7.3) and by 18.0 g (?26.6, ?9.4) for each 5 µg/m 3 increase in PM 2.5 and PM 10 , respectively, and by 15.9 g (?27.6, ?4.2) for each 10 µg/m 3 increase in NO 2 . Third trimester exposures (truncated at 37 gestational weeks) were associated with a decreased TBW by 48.1 g (?58.1, ?38.0) for PM 2.5 , 38.1 g (?46.7, ?29.6) for PM 10 and 14.7 g (?25.3, ?4.0) for NO 2 . Effects of pollutants on TBW were larger in rural areas. Conclusions: Our results support an adverse effect of air pollutant exposure on TBW. We highlighted a larger effect of air pollutants on TBW among women living in rural areas compared to women living in urban areas.

Keywords: air pollution; term birth weight; spatial autocorrelation; propensity score; doubly robust (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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