Urinary Metabolites of Organophosphate Pesticides among Pregnant Women Participating in the Japan Environment and Children’s Study (JECS)

Yukiko Nishihama, Shoji F. Nakayama, Tomohiko Isobe, Chau-Ren Jung, Miyuki Iwai-Shimada, Yayoi Kobayashi, Takehiro Michikawa, Makiko Sekiyama, Yu Taniguchi, Shin Yamazaki and on behalf of the Japan Environment and Children’s Study Group
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Yukiko Nishihama: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Shoji F. Nakayama: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Tomohiko Isobe: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Chau-Ren Jung: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Miyuki Iwai-Shimada: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Yayoi Kobayashi: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Takehiro Michikawa: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Makiko Sekiyama: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Yu Taniguchi: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
Shin Yamazaki: Japan Environment and Children’s Study Programme Office, Health and Environmental Risk Division, National Institute for Environmental Studies, Tsukuba 305-0053, Ibaraki, Japan
on behalf of the Japan Environment and Children’s Study Group: Membership of the Japan Environment and Children’s Study Group is provided in the Acknowledgements.

IJERPH, 2021, vol. 18, issue 11, 1-13

Abstract: Organophosphate pesticides (OPPs) exhibit neurodevelopmental toxicity. To evaluate the effect of prenatal exposure to OPPs in the Japan Environment and Children’s Study, a nationally representative birth cohort study, 4575 maternal urine samples were analysed for six OPP metabolites, i.e., dialkylphosphates (DAPs). This study aimed to investigate predictors of urinary DAPs using machine learning approaches and to assess the cumulative risk based on relative potency factors among Japanese pregnant women. The median creatinine-normalised urinary concentrations (interquartile ranges) of dimethylphosphate, dimethylthiophosphate and diethylphosphate, which had a detection rate of 50% or higher, were 3.53 (1.91–6.78), 4.09 (1.66–10.8) and 3.28 (1.88–5.98) µg/g-creatinine, respectively. Possible predictors of urinary DAP concentrations were the month of urine sampling, consumption of apple and maternal body mass index. When fenitrothion was used as an index chemical for cumulative risk assessment, 0.36% of participants exceeded the lower 95% confidence limit of the benchmark dose 10 .

Keywords: organophosphate pesticides; dialkylphosphates; urine; biomarker; pregnant women; birth cohort; cumulative risk assessment; relative potency factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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