Decrease in All-Cause 30-Day Mortality after Bacteraemia over a 15-Year Period: A Population-Based Cohort Study in Denmark in 2000–2014

Mona Katrine Alberthe Holm, Filip Jansåker, Kim Oren Gradel, Rikke Thoft Nielsen, Christian Østergaard Andersen, Jens Otto Jarløv, Henrik Carl Schønheyder and Jenny Dahl Knudsen
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Mona Katrine Alberthe Holm: Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
Filip Jansåker: Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen N, Denmark
Kim Oren Gradel: Center for Clinical Epidemiology, Odense University Hospital, 5000 Odense, Denmark
Rikke Thoft Nielsen: Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
Christian Østergaard Andersen: Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Kettegaard Alle 30, 2650 Hvidovre, Denmark
Jens Otto Jarløv: Department of Clinical Microbiology, Copenhagen University Hospital, Herlev and Gentofte, 2730 Herlev, Denmark
Henrik Carl Schønheyder: Department of Clinical Microbiology, Aalborg University Hospital, 9000 Aalborg, Denmark
Jenny Dahl Knudsen: Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen N, Denmark

IJERPH, 2021, vol. 18, issue 11, 1-12

Abstract: Introduction: Bacteraemia is a frequent infectious condition that strongly affects morbidity and mortality. The incidence is increasing worldwide. This study explores all-cause 30-day mortality after bacteraemia in two out of Denmark’s five healthcare regions with approximately 2.4 million inhabitants. Methods: Clinically significant bacteraemia episodes ( n = 55,257) were identified from a geographically well-defined background population between 2000 and 2014, drawing on population-based data regarding bacterial species and vital status. All-cause 30-day mortality was assessed in relation to bacteraemia episodes, number of patients with analysed blood cultures and the background population. Results: We observed a decreasing trend of all-cause 30-day mortality between 2000 and 2014, both in relation to the number of bacteraemia episodes and the background population. Mortality decreased from 22.7% of the bacteraemia episodes in 2000 to 17.4% in 2014 (annual IRR [95% CI]: 0.983 [0.979–0.987]). In relation to the background population, there were 41 deaths per 100,000 inhabitants in 2000, decreasing to 39 in 2014 (annual IRR [95% CI]: 0.988 [0.982–0.993]). Numbers of inhabitants, bacteraemia episodes, and analysed persons having BCs increased during the period. Conclusions: All-cause 30-day mortality in patients with bacteraemia decreased significantly over a 15-year period.

Keywords: bacteraemia; bloodstream infection; population-based study; mortality; epidemiology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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