Differential Laboratory Diagnosis of Acute Fever in Guinea: Preparedness for the Threat of Hemorrhagic Fevers

Vladimir G. Dedkov, N’Faly Magassouba, Olga A. Stukolova, Victoria A. Savina, Jakob Camara, Barrè Soropogui, Marina V. Safonova, Pavel Semizhon and Alexander E. Platonov
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Vladimir G. Dedkov: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint Petersburg, Russia
N’Faly Magassouba: Laboratoire de Virologie, Université Gamal Abdel Nasser de Conakry, Projet de Recherche sur les Fièvres Hémorragiques en Guinée, 001 B1568 Conakry, Guinea
Olga A. Stukolova: Central Research Institute for Epidemiology, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 111123 Moscow, Russia
Victoria A. Savina: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint Petersburg, Russia
Jakob Camara: Laboratoire de Virologie, Université Gamal Abdel Nasser de Conakry, Projet de Recherche sur les Fièvres Hémorragiques en Guinée, 001 B1568 Conakry, Guinea
Barrè Soropogui: Laboratoire de Virologie, Université Gamal Abdel Nasser de Conakry, Projet de Recherche sur les Fièvres Hémorragiques en Guinée, 001 B1568 Conakry, Guinea
Marina V. Safonova: Anti-Plague Center, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 119121 Moscow, Russia
Pavel Semizhon: The Republican Research and Practical Center for Epidemiology and Microbiology, 220114 Minsk, Belarus
Alexander E. Platonov: Pasteur Institute, Federal Service on Consumers’ Rights Protection and Human Well-Being Surveillance, 197101 Saint Petersburg, Russia

IJERPH, 2021, vol. 18, issue 11, 1-15

Abstract: Acute febrile illnesses occur frequently in Guinea. Acute fever itself is not a unique, hallmark indication (pathognomonic sign) of any one illness or disease. In the infectious disease context, fever’s underlying cause can be a wide range of viral or bacterial pathogens, including the Ebola virus. In this study, molecular and serological methods were used to analyze samples from patients hospitalized with acute febrile illness in various regions of Guinea. This analysis was undertaken with the goal of accomplishing differential diagnosis (determination of causative pathogen) in such cases. As a result, a number of pathogens, both viral and bacterial, were identified in Guinea as causative agents behind acute febrile illness. In approximately 60% of the studied samples, however, a definitive determination could not be made.

Keywords: Guinea; zoonotic pathogens; acute febrile illness; diagnostics; fever (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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