The Effect of Bilateral Nephrectomy on Renalase and Catecholamines in Hemodialysis Patients

Magda Wiśniewska, Natalia Serwin, Violetta Dziedziejko, Małgorzata Marchelek-Myśliwiec, Barbara Dołęgowska, Leszek Domański, Kazimierz Ciechanowski, Krzysztof Safranow, Tomasz Gołębiowski and Andrzej Pawlik
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Magda Wiśniewska: Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Natalia Serwin: Immunology and Laboratory Medicine, Department of Microbiology, Pomeranian Medical University, 70-111 Szczecin, Poland
Violetta Dziedziejko: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
Małgorzata Marchelek-Myśliwiec: Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Barbara Dołęgowska: Immunology and Laboratory Medicine, Department of Microbiology, Pomeranian Medical University, 70-111 Szczecin, Poland
Leszek Domański: Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Kazimierz Ciechanowski: Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Krzysztof Safranow: Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland
Tomasz Gołębiowski: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland
Andrzej Pawlik: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland

IJERPH, 2021, vol. 18, issue 12, 1-13

Abstract: Background/Aims: Renalase is an enzyme with monoamine oxidase activity that metabolizes catecholamines; therefore, it has a significant influence on arterial blood pressure regulation and the development of cardiovascular diseases. Renalase is mainly produced in the kidneys. Nephrectomy and hemodialysis (HD) may alter the production and metabolism of renalase. The aim of this study was to examine the effect of bilateral nephrectomy on renalase levels in the serum and erythrocytes of hemodialysis patients. Methods: This study included 27 hemodialysis patients post-bilateral nephrectomy, 46 hemodialysis patients without nephrectomy but with chronic kidney disease and anuria and 30 healthy subjects with normal kidney function. Renalase levels in the serum and erythrocytes were measured using an ELISA kit. Results: Serum concentrations of renalase were significantly higher in post-bilateral nephrectomy patients when compared with those of control subjects (101.1 ± 65.5 vs. 19.6 ± 5.0; p < 0.01). Additionally, renalase concentrations, calculated per gram of hemoglobin, were significantly higher in patients after bilateral nephrectomy in comparison with those of healthy subjects (994.9 ± 345.5 vs. 697.6 ± 273.4, p = 0.015). There were no statistically significant differences in plasma concentrations of noradrenaline or adrenaline. In contrast, the concentration of dopamine was significantly lower in post-nephrectomy patients when compared with those of healthy subjects (116.8 ± 147.7 vs. 440.9 ± 343.2, p < 0.01). Conclusions: Increased serum levels of renalase in post-bilateral nephrectomy hemodialysis patients are likely related to production in extra-renal organs as a result of changes in the cardiovascular system and hypertension.

Keywords: renalase; kidney; erythrocytes; bilateral nephrectomy; chronic kidney disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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