Sero-Prevalence of SARS-CoV-2 Antibodies in High-Risk Populations in Vietnam

Tasnim Hasan, Thach Ngoc Pham, Thu Anh Nguyen, Hien Thi Thu Le, Duyet Van Le, Thuy Thi Dang, Trang Dinh Van, Yen Ngoc Pham, Ha Viet Nguyen, Giang Linh Tran, Nguyen Van Thi Cam, Thanh Trung Nguyen, Viet Quang Truong, Than Huu Dao, Chung Thanh Le, Nam Tan Truong, Hoang Trung Vo, Phuc Thanh Le, Thao Thanh Nguyen, Vinh Van Luu, Vinh Dai Nguyen, Brett G. Toelle, Guy B. Marks and Greg J. Fox
Additional contact information
Tasnim Hasan: Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia
Thach Ngoc Pham: National Hospital for Tropical Diseases, Hanoi 12319, Vietnam
Thu Anh Nguyen: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Hien Thi Thu Le: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Duyet Van Le: National Hospital for Tropical Diseases, Hanoi 12319, Vietnam
Thuy Thi Dang: National Hospital for Tropical Diseases, Hanoi 12319, Vietnam
Trang Dinh Van: National Hospital for Tropical Diseases, Hanoi 12319, Vietnam
Yen Ngoc Pham: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Ha Viet Nguyen: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Giang Linh Tran: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Nguyen Van Thi Cam: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Thanh Trung Nguyen: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Viet Quang Truong: Hanoi Center for Disease Control (CDC), Hanoi 11512, Vietnam
Than Huu Dao: Hanoi Center for Disease Control (CDC), Hanoi 11512, Vietnam
Chung Thanh Le: Da Nang Centre for Disease Control, Da Nang City 50213, Vietnam
Nam Tan Truong: Da Nang Centre for Disease Control, Da Nang City 50213, Vietnam
Hoang Trung Vo: Quang Nam Centre for Disease Control, Quang Nam 51108, Vietnam
Phuc Thanh Le: Da Nang Lung Hospital, Da Nang City 50606, Vietnam
Thao Thanh Nguyen: Quang Nam Pham Ngoc Thach Hospital, Quang Nam 51110, Vietnam
Vinh Van Luu: Quang Nam Pham Ngoc Thach Hospital, Quang Nam 51110, Vietnam
Vinh Dai Nguyen: Hoa Vang District Health Center, Da Nang City 50807, Vietnam
Brett G. Toelle: Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia
Guy B. Marks: The Woolcock Institute of Medical Research, Glebe 2037, Australia
Greg J. Fox: Faculty of Medicine and Health, The University of Sydney, Sydney 2006, Australia

IJERPH, 2021, vol. 18, issue 12, 1-13

Abstract: As a response to the coronavirus disease 2019 (COVID-19) pandemic, Vietnam enforced strict quarantine, contact tracing and physical distancing policies resulting in one of the lowest numbers of individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) globally. This study aimed to determine the prevalence of SARS-CoV-2 antibody positivity among high-risk populations in Vietnam. A prevalence survey was undertaken within four communities in Vietnam, where at least two COVID-19 cases had been confirmed. Participants were classified according to the location of exposure: household contacts, close contacts, community members, and healthcare workers (HCWs) responsible for treating COVID-19 cases. Participants completed a baseline questionnaire and SARS-CoV-2 IgG antibodies were quantified using a commercial assay. A total of 3049 community members and 149 health care workers consented to the study. Among 13 individuals who were seropositive (0.4%), five household contacts (5/27, 18.5%), one close contact (1/53, 1.9%), and seven community members (7/2954, 0.2%) had detectable SARS-CoV-2 antibodies. All HCWs were negative for SARS-CoV-2 antibodies. Participants were tested a median of 15.1 (interquartile range from 14.9 to 15.2) weeks after exposure. Our study found a low prevalence of SARS-CoV-2 antibodies in high-risk communities and healthcare workers in communities in Vietnam with known COVID-19 cases.

Keywords: COVID-19; SARS-CoV-2; seroprevalence; Vietnam (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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